Now-a-days, FPGAs are even used as prototyping devices. With the ongoing technologies to build these devices, FPGAs are becoming larger, faster and more accurate. With the proper development environments, FPGAs can also be used in end products to provide specialized features that are not always possible with ASIC chips such as in-field updates of hardware. Partial Re-configuration can be used to maximize the resource utilization in FPGAs. The partial re configuration with FPGA can be used in Bio application at run-time. This application can be considered to monitor and measure various health parameters viz., Body-Temperature, Heart Rate, ECG, Oxygen Saturation and Blood-Pressure etc. In this research article, the runtime partial reconfiguration using VHDL coding in Xilinx tool has been performed.