Figure S1 Secondary structures of E. coli and B. subtilis RNase P ribozymes. (A, B) Nucleotide sequences and secondary structures of the E. coli (A) and B. subtilis (B) RNase P ribozymes with circular permutation. (C) The sys-1 (top) and sys-2 (bottom) bimolecular forms of the E.coli RNase P ribozyme. (D) The sys-1 (top) and sys-2 (bottom) bimolecular forms of the B. subtilis RNase P ribozyme.

No abstract

Polyamines are a promising class of molecules that can modulate RNA enzyme activities. To analyze the effects of the number of amine moieties systematically, we employed four polyamines sharing dimethylene units to connect amine moieties. As a model RNA enzyme, we used a structurally unstable group I ribozyme, which was activated most and least efficiently by tetraethylenepentamine and diethylenetriamine respectively.

No abstract

Alzheimer's disease (AD) is the most common etiology of dementia amongst aged individuals and a principal public health-related abnormality. It is considered as a multifactorial disorder, with no particular origin identified, and also some modifiable, as well as non-modifiable threats are correlated with its progression and development. The endoplasmic reticulum (ER) stress response is considered as a key process in the pathogenesis of AD. In this chapter, the authors present a summary of related transmembrane kinase proteins responsible for the onset of AD as well as show the interrelationship between ER stress and AD. Finally, the authors demonstrate the therapeutics intervention for AD diagnosis by highlighting the current practices to advance novel therapies.