As an atypical member of the Rho family small GTPases, RhoH shares less than 50% sequence similarity with other members, and its expression is commonly observed in the haematopoietic lineage. To date, RhoH function was observed in regulating T cell receptor signalling, and less is known in other haematopoietic cells. Its activation may not rely on the standard GDP/GTP cycling of small G proteins and is thought to be constitutively active because critical amino acids involved in GTP hydrolysis are absent. Alternatively, its activation can be regulated by other types of regulation, including lysosomal degradation, somatic mutation and transcriptional repressor, which also results in an altered protein expression. Aberrant protein expression of RhoH has been implicated not only in B cell malignancies but also in immune-related diseases, such as primary immunodeficiencies, systemic lupus erythematosus and psoriasis, wherein its involvement may provide the link between immune-related diseases and cancer. RhoH association with these diseases involves several other players, including its interacting partner, ZAP−70; activation regulators, Vav1 and RhoGDI and other small GTPases, such as RhoA, Rac1 and Cdc42. As such, RhoH and its associated proteins are potential attack points, especially in the treatment of cancer and immune-related diseases.

Textile industry effluent contains a high amount of toxic colorants. These dyes are carcinogenic and threats to the environment and living beings. In this study, poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-co-HFP) was used as the based polymer for PIMs with bis-(2-ethylhexyl) phosphate (B2EHP) and dioctyl phthalate (DOP) as the carrier and plasticizer. The fabricated PIMs were employed to extract the cation dye (Malachite Green; MG) from the feeding phase. PIMs were also characterized by scanning electron microscopy (SEM), atomic force microscope (AFM), contact angle, water uptake, Fourier-transform infrared spectroscopy (FTIR) and ions exchange capacity. The performance of the PIMs was investigated under various conditions such as percentage of carrier and initial dye concentration. With permeability and flux values of 0.1188 cm/min and 1.1913 mg cm/min, PIM produced with 18% w/w PVDF-co-HFP, 21% w/w B2EHP, 1% w/w DOP and 40% w/w THF and was able to achieve more than 97% of MG extraction. The experimental data were then fitted with a pseudo-second-order (PSO) model, and the calculated R2 value was ~0.99. This shows that the data has a good fit with the PSO model. PIM is a potential alternative technology in textile industry effluent treatment; however, the right formulation is crucial for developing a highly efficient membrane.

Summary A membrane‐less microbial fuel cell (ML‐MFC) is an electrochemical device that incorporates microorganisms into the design in order to produce electricity through biologically catalyzed oxidation of soluble, electron‐donating substrates. In this study, three lignocellulosic raw materials were added into the ML‐MFC whereby the sludge acted as the pseudomembrane. All three materials were used as the substrates in ML‐MFC for the production of electricity that was measured using a digital multimeter. Results showed that the ML‐MFC that contained sludge supplemented with banana peel produced the highest electricity, followed by corn bran and palm oil mill effluent (POME) at 237.1 mV (23.75 mW/m2), 176.8 mV (12.65 mW/m2), and 138 mV (22.03 mW/m2) after 138 h, 192 h, and 108 h of incubation period, respectively. For the control test (sludge only), about 162.7 mV was recorded at shorter incubation period (84 h). This showed that long‐term operation of the ML‐MFC using these complex lignocellulosic compounds as a direct substrate for electricity generation is feasible, though their degradation is slow.

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