Cases of overweight and obesity in the world increased continuously. In 2016, obesity increased by 3% in men and 6% in women compared to 1975. Overweight cases also increased by 20% in men and 23% in women compared to 1975. Overweight and obesity have been linked to an increase in adipose tissue in the body. Increased adipose tissue associated with inflammation, which one of its characteristics is an increase levels of C - Reactive Protein (CRP). This article aim is to describe the mechanism of physical exercise to diminish CRP level in overweight and obesity. Adipose tissue produces and releases various pro-inflammatory and anti-inflammatory factors such as leptin, adiponectin, resistin, TNF-α, IL-6, MCP-1 and CRP. One of the prevention and treatment of inflammatory for overweight and obesity cases is to do physical exercise. In cases of overweight and obesity, the physical exercise aims to increase energy expenditure. Physical exercise decreases the volume and amount of adipose and pre-adipose tissue as well as the number of endothelial cells and macrophages in adipose that contain pro-inflammation such as IL-1, TNF-α, CRP, serum amyloid protein (SAA), and cytokines. Physical exercise rises anti-inflammatory properties such as IL-10, IL-1ra which play a role in inhibiting the transduction of IL-1β signals and inhibiting TNF-α synthesis. Physical exercise also amplifies antioxidant enzymes such as SOD and GPX. The antioxidants play a role in fighting free radicals to reduce inflammation.

This study aims to analyze the effect of the combination of intermittent calorie restriction and moderate intensity interval training (MIIT) on serum c-reactive protein (CRP) levels as one of the inflammatory mediators and blood glucose levels in female mice exposed to a-high glycemic index diet. The sample of this study was female mice Balb/c strain, divided into four groups:, the control group (con), the intermittent calorie restriction group (restrict), the MIIT group (interv), and the combine group of intermittent calorie restriction and moderate-intensity interval training (restrict+interv). A high glycemic index diet was a high calorie and was provided by standard feed and oral gavage of 0.013 g/gBW glucosesolution. Intermittent calorie restriction was 50% reduction of the standard feed 3x/week. The MIIT was five-minute intervals of swimming and 30 seconds of passive rest consecutively for 30 minutes and 3x/week. Meanwhile, the treatment duration was four weeks. The oral glucose tolerance test consisting of fasting blood glucose (FBG) and a two-hour post -prandial (2HPP) blood glucose was measured before and after the treatment. CRP was examined only after the treatment. The restrict + interv group had a significant reduction in CRP levels compared to the restricted group (p = 0.005) and the interv group (p = 0.044). The FBG levels the restrict + interv group and restricted group had a significant decrease (p = 0.026). Moreover, 2HPP of the restrict + interv group and restricted group had a significant decline (p = 0.000). This study concludes that the combination of intermittent calorie restriction and moderate -intensity interval training can attenuate elevated serum CRP and blood glucose levels.