Introduction: To determine the antibiotic sensitivity patterns of common pathogens in pus samples from different wounds. Material and Methods: A total of 110 positive pus samples were selected for the study. These samples were received in the Microbiology laboratory of Arif Memorial Teaching Hospital, Lahore, from July to December 2017. These samples were processed and identified by standard protocols of aerobic culture and sensitivity. Antibiotic susceptibility test was done according to CLSI guidelines. Result: Among the total 110 positive cases, 70 (64%$ were male and 40 (36%$ were females admitted in different departments of the hospital during the study time. Nine different organisms were isolated. Among them, Staphylococcus aureus was the most common isolate followed by Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae. Citrobacter, Proteus and Enterococcus contributes were less common. The sensitivity of Staphylococcus aureus was highest with Vancomycin and Gentamycin, whereas Pseudomonas and Enterbacteriaceae were sensitive with Imepenem. Conclusion: Antimicrobial resistance always pose challenge for clinicians in treating pyogenic infection. The development of resistant strains of pathogens can be limited by the judicious use of antibiotics. Proper knowledge of antibiotics in treating pyogenic infection leads to patient satisfaction and short hospital stay.