Background: Hyperthyroid is a hypermetabolic condition caused by abnormal thyroid gland function resulting in overproduction and overexpression of thyroid hormone. The prevalence of hyperthyroid during pregnancy is 0.1-0.4%, where 85% of case are presented as grave’s disease. Objective: To report the treatment of uncontrolled hyperthyroid during pregnancy.Method: Case Report Case:  Ms. S, Female, 33 years old, presenting with brethlessness since 5 days before admission. Breathlessness persist and aggravated by lying down position. The patient has history of hyperthyroid since 1 years before admission. The blood pressure was 120/80 mmHg, respiration rate 28 times/min, and body temperature 36,7oC. Uterus fundal height 26 cm, cephalic presentation, fetal heart rate 130 times/min, single fetus intrauterine and alive. Laboratoric test for leukocyte: 21,300/ul, T4 level 22.8 mg/dl dan T3 level 2.9 mg/dl. The patient diagnosed with G3P2A0 31-week gestational age single alive fetus intrauterine with uncontrolled hyperthyroid and bilateral pleural effusion. Treatment consist of propylthiouracil as the drug of choice for anti-thyroidal drug, nifedipine for gestational hypertension and furosemide to treat the pleural effusion.  Conclusion: History taking, physical examination, thyroid function test, and maintaining euthyroidism during pregnancy is a key to reduce the risk of maternal and fetal complication.Keywords: hyperthyroid, pregnancy , IUGR

BACKGROUND: Hyperthyroid is a hypermetabolic condition caused by abnormal thyroid gland function resulting in overproduction and overexpression of thyroid hormone. The prevalence of hyperthyroid during pregnancy is 0.1-0.4%, where 85% of case are presented as grave’s disease. OBJECTIVE: To report the treatment of uncontrolled hyperthyroid during pregnancy.METHOD: Case Report CASE:  Ms. S, Female, 33 years old, presenting with brethlessness since 5 days before admission. Breathlessness persist and aggravated by lying down position. The patient has history of hyperthyroid since 1 years before admission. The blood pressure was 120/80 mmHg, respiration rate 28 times/min, and body temperature 36,7oC. Uterus fundal height 26 cm, cephalic presentation, fetal heart rate 130 times/min, single fetus intrauterine and alive. Laboratoric test for leukocyte: 21,300/ul, T4 level 22.8 mg/dl dan T3 level 2.9 mg/dl. The patient diagnosed with G3P2A0 31-week gestational age single alive fetus intrauterine with uncontrolled hyperthyroid and bilateral pleural effusion. Treatment consist of propylthiouracil as the drug of choice for anti-thyroidal drug, nifedipine for gestational hypertension and furosemide to treat the pleural effusion.  CONCLUSION: History taking, physical examination, thyroid function test, and maintaining euthyroidism during pregnancy is a key to reduce the risk of maternal and fetal complication.KEYWORDS : hyperthyroid, pregnancy, IUGR

Preeclampsia is a hyperdynamic condition that is syndromed by hypertension and proteinuria after 20 weeks of pregnancy. Preeclampsia incident is the first cause of 6-8 % number morbidity/mortality maternity and fetus in the world. Preeclampsia is related to the disability of physiology adaptation that can decrease perfusion of uteroplacental. Xanthone derivatives in mangosteen have been reported to possess a wide range of biological properties, including antioxidant and antihypertensive activities. Eugenol is a primary component of basil oil. It is known for its antioxidant, antiinflammatory, and vasorelaxant actions. These beneficial effects of eugenol make it an excellent therapeutic candidate for the treatment of hypertensive disorders of pregnancy. This study wants to analyze the best available research evidence on the potential combination of xanthone compounds from mangosteen fruit (Garcinia mangostana) with eugenol compounds in basil leaf (Ocimum sanctum) as an alternative therapy in preeclampsia.  A literature review was conducted in the electronic databases PubMed and Google Scholar using the index terms "xanthone" and "eugenol" and "hypertension" and "preeclampsia." All types of studies were included for this study, such as randomized controlled trials, systematic reviews, literature reviews, and pilot studies published between 2010 and 2021. Articles which not written in English were excluded from the study. This search resulted in 10 papers. Antioxidant properties of mangosteen peel extract compounds derived from xanthone, the most significant component is α-mangosteen and γ-mangosteen. Eugenol is vasorelaxant action by increasing the expression of its target genes, Sarco/endoplasmic reticulum Ca²⁺-ATPase and adequate potassium-calcium-activated potassium channels channel, thereby relaxing vascular smooth muscle cells and decreasing blood pressure. With this review, we suggest that eugenol, which is a vasorelaxant combined with xanthone which is an antioxidant by obstructing free radical and oxidative stress, can be a potent therapeutic for preeclampsia and intend to motivate researchers (e.g., chemistry, biology, pharmaceutical, and therapeutic areas) to provide evidence of these compounds for the management of preeclampsia.