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We aimed to report the case of a Pakistani female who presented with MMD and hyperthyroidism, and the worldwide literature review of the case reports on MMD associated with hyperthyroidism. Methods: The study was carried out using PRISMA’s recommendations. An electronic search on PubMed, Cochrane Library, and Google Scholar was carried out. Articles explaining the association between Moyamoya disease and thyroid-related diseases were included. Results: A total of 31 studies were included in the review, with the preponderance of Japanese females. The review has systematically compiled in detail all the aspects of moyamoya syndrome and thyroid disorders- from detailed histories of the included patients to the treatment interventions used and their outcomes. Conclusion: The authors are with the suggestion that more cases of MMD and its association with other major factors should be presented in Pakistan as well as in all parts of the world.

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To the EditorAn article published recently by Voss et al. 1 "Anatomical reasons for failure of dual-filter cerebral embolic protection application in TAVR: A CT-based analysis" has interested us in it as it provides a vast amount of knowledge to its readers. The authors did remarkable work in trying to explain the relationship and tried to convey it as best they could. We would certainly not hesitate to state that it was a pleasure to read such incredible work by the authors. We agree with the authors that specific anatomical reasons may lead to dual-filter cerebral embolic protection failure. However, we would like to highlight a few points that would improve the quality of the document by mentioning them.