Background: High mortality rate around the globe has been reported due to diarrheal disease among all fewer than five years of age. Many studies show their utilization in the treatment of diarrheal disease especially among children of under-five. Objective: To assess the treatment outcome of diarrhea with and without probiotics among children aged 12-60 months. Methodology: This comparative cross-sectional study was undertaken from July to December 2017. A pre-designed questionnaire was used to collect the information in terms of antibiotics, rehydrating agents, antipyretic agents, and probiotics. A total of 109 patients were selected randomly and then divided into two groups as "probiotic" having 55 children and "Non-Probiotic", having 54 children. Guardians of patients were contacted telephonically after 48 hours and 72 hours to ask about the time frame of relief from symptoms, diarrheal episodes, and cure from disease. Data were analyzed by using SPSS 20. Results: Out of 109 patients, 54 patients were in the non-probiotic group and 55 in the probiotic group. The overall age of patients remained 31±12 months. Saccharomyces boulardii (56.4%) and Lactobacillus GG (43.6%) were probiotics prescribed by pediatric physicians. A significant difference (p=0.000) was observed in terms of treatment outcome showing early relief (12 hrs) 43 (78%) vs 22 (41%) in probiotic vs non-probiotic group and early cure (<48 hrs) from diarrhea in probiotic group 48 (87%) vs 35 (65%) as compared to the non-probiotic group. (p=0.00) Conclusion: The use of probiotics during the treatment of acute diarrhea among children below five years shortens the duration of symptoms and helps the cure as early as one day before the patients' not using probiotics.

ABSTRACT… Breast carcinomas are an uncommon neoplastic condition in men, which accounts for only 1% of all breast cancers, and not more than 1% of all malignancies in men. A 55 years old man presented with a ulcerated mass in the left breast with a history of pain, discharge and fever. On examination, there was an ulcerating growth above the left nipple with numerous maggots. The fine needle aspiration cytology confirmed the ductal cell carcinoma which was further confirmed by ulcer edge biopsy. Key words:Neoplasia; Ductal cell carcinoma; Breast cancer.

Objective: To determine effect of iron deficiency anemia on the patients developing surgical site infection at surgical department of a tertiary care setup in Pakistan. Study Design: Comparative prospective study. Place and Duration of Study: Department of Surgery, Pak Emirates Military Hospital Rawalpindi, from Nov 2018 to Mar 2019. Methodology: A total of 152 indoor hospitalized patients were included in the study. Surgical site infection was assessed by a consultant surgeon according to definitions provided by the Centers for Disease Control and Prevention (CDC) National nosocomial infections surveillance system. Iron deficiency anemia was classed on the basis of hemoglobin and ferritin levels. Results: Eighty six (56.6%) patients were male while 66 (43.4%) patients included in the study were female. Commonest surgical procedure was laparotomy 29 (19.1%) followed by the hernioplasty 27 (17.7%). Out of 152 patients undergoing surgery & admitted in ward, 35 (23.1%) showed the presence of surgical site infection while 117 (76.9%) had no infection. Seventy eight (51.3%) patients had iron deficiency anemia while 74 (48.7%) patients were not anemic. History of transfusion during the surgery and presence of iron deficiency anemia was significantly associated with surgical site infection in the target population. Conclusion: Study exhibited high frequency of surgical site infection in the target population. Regular screening for anemia should be performed at surgery department and patients with history of transfusion during the surgery should be looked after especially. Iron deficiency anemia emerged as an independent factor associated with presence of surgical site infection among surgical patients.

Objective: To assess the bacteriological profile of infected diabetic foot and its relationship with limb salvation among the patients treated for diabetic foot infection at a tertiary setup.Study Design: Correlational study. Place and Duration of Study: Department of Surgery, Pak Emirates Military Hospital Rawalpindi, from Dec 2018 to Mar 2019. Methodology: A total of 160 cases of infected diabetic foot were included in the study. Diagnosis of diabetic foot was made by the consultant surgeon and bacteriological analysis was done on the specimen by the microbiology laboratory of the same hospital. Relationship of bacteriological profile and other socio-demographic factors was assessed with limb salvation in these patients. Results: There were 121 (75.6%) male patients while females were 39 (24.4%). Commonest organism found was Staphylococcus aureus 49 (30.6%) which was followed by pseudomonas 39 (24.4%). Out of 160 patients treated for the diabetic foot infection, 71 (48.4%) had to undergo the process of limb salvation while 89 (51.6%) were managed conservatively. Poly-microbial infection and raised body mass index (BMI) were significantly associated with limb salvation in the target populace (p-value <0.05). Conclusion: This study depicted high frequency of patients undergoing limb salvation due to diabetic foot infections in our setup. Patients with raised body mass index and those with poly-microbial infection on the culture should be specially attended in order to avoid this irreversible damage to the patient in the process of saving his life from the infective process.