Introduction: Infectious keratitis is one of the main causes of visual impairment. The incidence of acanthamoeba keratitis is relatively rare, while the prevalence is around 1 to 9 cases per 100.000. One of the factors supporting the occurrence of acanthamoeba keratitis is the increasing use of contact lenses around the world. Content: When there is microtrauma to the cornea, it can cause the expression of the mannose on the surface. With the emergence of mannose in the form of glycoproteins, it will be a requirement for the attachment of Acanthamoeba spp. Conclusion: Keratitis Acanthamoeba is an infectious disease of the cornea due to the use of contact lenses that are too long exposed to water which causes the entry of Acanthamoeba. This disease has a good prognosis with immediate drug administration within the first 3 weeks after the onset of symptoms.