Background:The stiffness of the large elastic arteries increase the morbidity and mortality. The purpose of the present study was to estimate the risk of aortic stiffness among end stage renal disease patients on maintenance haemodialysis. Methods:This cross-sectional study was carried out in the a period of two years. Chronic kidney disease in stage 5 ] patients older than 18 years on maintenance haemodialysis (MHD) for more than 3 months were designated as case group and age and sex matched non CKD patients were considered as control group. Serum calcium, serum albumin, serum phosphate and iPTH were estimated by semi-automated biochemistry analyzer from the Department of Biochemistry of NIKDU, Dhaka and NICVD, Dhaka. Plain Xray abdomen in lateral view was performed for all patients.Result: A total number of 100 patients were enrolled for this study of which 50 patients were in end stage renal disease (ESRD) group and the rest 50 patients were in non-CKD group. Mean (±SD) aortic stiffness index was significantly higher (P<0.001) among ESRD population (3.27±1.70) compared to non CKD group of population (2.00±0.73). Mean (±SD) serum calcium (corrected) level was significantly high (P<0.001) in ESRD patients (9.79±0.87) compared to non CKD group of population (9.13±0.70). Mean (±SD) serum phosphate level was significantly higher (P<0.001) in ESRD patients (5.71±0.96) compared to non CKD group of population (4.20±0.59). However, mean (±SD) iPTH level showed no significant difference between ESRD (25.33±51.98) and non CKD group of population (38.53±19.52). Conclusion:In conclusion, aortic stiffness is significantly higher among ESRD subjects.

Background: Numerous negative outcomes of Chronic Kidney Disease (CKD) receiving maintenance haemodialysis (MHD) are linked to secondary hyperparathyroidism (SPTH), hypocalcaemia and hyperphosphataemia. Its management is difficult for these patients. Currently, appropriate haemodialysis (HD) is maintained, and parathyroid hormone (PTH) is reduced with vitamin D receptor analogs (VDRA) and/or calcimimetics or parathyroidectomy. Objective: The main objective of this study was to evaluate the status of parathyroid hormone in maintenance Hemodialysis patients in Bangladesh. Method: This observational study was conducted in the haemodialysis unit of National Institute of Kidney Disease and Urology (NIKDU) and Bangladesh Institute of Research & Rehabilitation on Diabetes, Endocrine and Metabolism (BIRDEM). Patients getting maintenance haemodialysis in NIKDU and BIRDEM were enrolled in this study. Results: The mean age of the patients was 50.4±13.13 years. Male female ratio was 1.3:1. The mean BMI was 23.5±4.7 kg/m2 with range from 15.6 to 45.5 kg/m2. 114(95.0%) patients had HTN and 56(46.7%) patients had DM. The duration of haemodialysis was 25.55±25.0 months and 71 (59.2%) patients had twice haemodialysis session/weeks. Mean duration on hemodialysis was 23 ± 19 months (Range 2-124). Conclusion: The majority of our hemodialysis patients weren't dialyzed properly.