New reaction routs were performed for the compound 5,5-diphenyl 2,4imidazolidinedione (I) to give derivatives (II -VII). These reactions include acylation, halogenation, reduction, and nucleophilic substitutions.Most of the derivatives showed variable chemical reactivities and thermal stability, and the N 1 and N 3 disubstituted analogue were found much less stable, and hydrolyzes easily in the reaction medium. According to 1 H and 13 C NMR measurement's, 1,3-Dichloro-5,5-diphenyl imidazolidine-2,4-dione (V) was found to chlorinate the methyl group of the solvent DMSO-d6. Sodium hydroxide consumption analysis was established to reveal the molecularity against NaOH, by following acidbase volumetric method.