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Murraya koenigii (MK) plants are a type of plant whose bioactive compounds have been widely used in various countries as traditional medicines with metabolites containing alkaloids, flavonoids, tannins, steroids/triterpenoids and anthraquinones. The purpose of this study was to determine of acute toxicity effect and to test the antifungal effects of ointment MK ethanol extract. Acute toxicity testing is carried out with the initial stage of testing at a dose of 0.05. The formulated ointment was subjected to an organoleptic evaluation test, pH, spreadability, and homogeneity. MK leaves ethanol extract can be formulated into ointment because it is safe to use with an LD50 value >2000mg/kgBW. The concentrations of 12.5% and 25% were the best concentration to inhibit the growth of Candida albicans.