Pendidikan adalah segala pengalaman yang dilalui peserta didik dengan segala lingkungan sepanjang hayat, Dalam pengertian yang luas, pendidikan dapat diartikan sebagai proses dengan metode-metode tertentu sehingga orang memperoleh pengetahuan, pemahaman, dan cara bertingkah laku yang sesuai dengan kebutuhan. Sedangkan sosial bisa dikatakan ilmu yang menyelidiki aspek sosio kultural pendidikan manusia itu sendiri. Sosial juga bisa sebagai acuan dalam berinteraksi antara manusia dengan masyarakat yang berfungsi untuk mengatur tindakan yang dimunculkan oleh individu di masyarakat. Berdasarkan konteks penelitian di atas penulis melakukan penelitian tentang “Implementasi Nilai-Nilai Kepedulian Sosial Pada Peserta Didik Melalui Mata Pelajaran Al-Qur’an Hadits kelas XII (Studi kasus di MAN 8 Jombang)” dengan menggunakan 3 fokus penelitian sebagaimana berikut: (1) Bagaimana peran guru mata pelajaran Al-Qur’an Hadits dalam menumbuhkan nilai-nilai kepedulian sosial pada peserta didik di MAN 8 Jombang. (2) Bagaimana implementasi nilai-nilai kepedulian sosial pada peserta didik di MAN 8 Jombang. (3) Apakah faktor-faktor pendukung dalam menumbuhkan nilai-nilai kepedulian sosial pada peserta didik di MAN 8 Jombang. Penulis menggunakan jenis penelitian deskriptif kualitatif dengan pendekatan kualitatif. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Untuk teknik analisis data peneliti menggunakan: reduksi data, display data, verifikasi data dan kesimpulan. Untuk pengecekan keabsahan data dengan cara: uji kredibilitas, pengujian transferability, pengujian dependability dan pengujian konfirmability. Hasil penelitian menunjukkan bahwa: (1) guru memiliki peran penting dalam menumbuhkan nilai-nilai kepedulian sosial di Madrasah. (2) Implementasi nilai-nilai kepedulian sosial melalui mata pelajaran al-qur’an hadits berjalan dengan baik dan berhasil, baik di lingkungan Madrasah maupun masyarakat. (3) faktor pendukung dan penghambat, faktor pendukungnya adalah lingkungan sekitar dan teman-teman sebaya, faktor penghambatnya adalah mengontrol siswa yang banyak di Madrasah membutuhkan waktu yang lama.

Malaria is an infectious disease caused by Plasmodium sp with the highest clinical incidence of 12.07% in Indonesia. New anti-malaria compounds are needed to replace antimalarial drugs that are already resistant nowadays. One of the efforts to find a new anti-malaria drug is through research on traditional medicinal plants used by Indonesian tribes from the ethnopharmacology database. In silico studies provide saving solutions in the process of computer-aided drug design. Histo-aspartic protease (HAP) is essential for the growth of Plasmodium falciparum and has been validated as an antimalarial drug target. Therefore, molecular docking was used to provide new insights into the development of drugs by targeting HAP protease. There are 238 compounds from 43 medicinal plants used as targeting ligand in this study prepared by Autodock Vina for an automated docking tool. The comprehensive docking protocol was valid showed by the RMSD value of 1,275 Å. The result obtained that AM50 (borrasosides A) from Borassus flabellifer was found to have the least affinity score of -10.1 kcal/mol higher compared to the native ligand. In conclusion, we are assuming that the mechanism of borrasosides A compound might get involved with HAP. Further protocols are required to prove the HAP inhibition towards Plasmodium falciparum.

The anti-malarial potency of Indonesian medicinal plants was evaluated through computational study. From 43 Indonesian medicinal plants, 238 previously reported compounds were carefully docked into HAP (histo-aspartic protease) with codename 3FNT in which the enzyme plays an important catalytic role in Plasmodium falciparum innate metabolism. Exhaustive docking experiments produced 6 best hits molecules including AM210 (4-hydroxy-3-methoxy strychnine), AM213 (protostrychnine), and AM216 (pseudostrychnine) which have less free energy compared to HAP native ligand, 1,2-ethanediol. This study revealed the potency of Strychnos nux-vomica L. as a source for antimalaria and support its traditional claims.

Malaria is one of the major causes of death in tropical and sub-tropical countries, caused by the infection of the protozoan parasite (Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, and Plasmodium knowlesi). As the prevalence of parasite drug-resistant strains increasing, alternative medicine to eliminate malaria is needed. In this study, a molecular docking protocol was employed to predict and select natural compounds from Indonesian medicinal plants as an antimalarial drug candidate. The docking protocol was validated by the RMSD value of crystal versus docking calculation. From 43 species of plants, 238 total compounds were collected and docked into Plasmepsin IV (PMIV) enzyme which plays a role in the nutrition uptake of Plasmodium in human blood circulation. This enzyme was collected from a protein database with codename 5I70. The protocol was produced an acceptable RMSD value of 1.435 Å. The docking experiment resulted in AM202 (Cassiamin B) from Cassia siamea as the best potent Plasmepsin IV inhibitor. This compound has the potential candidate for future anti-malarial drugs. Cassiamin B had an affinity value of -11.2 kcal/mol which was higher than PMIV's native ligand (-3.8 kcal/mol).

Infectious diseases are one of the leading causes of mortality and morbidity in the world that can be treated with antibiotics. The existence of resistance can threaten the effectiveness of antibiotics. This study aims to find new antibiotic candidates from fungi in estuary soils and tested the activity against Pseudomonas aeruginosa bacteria. Estuary soil ecosystems have extreme conditions that require microorganisms to be able to survive Soil samples were taken from the Estuary of the Kalinaun Village, East Likupang District, North Minahasa Regency, North Sulawesi Province. Soil samples obtained were 4 isolates of fungi that had the potential bacteria inhibition, namely IS2-