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Aim: To compare the efficacy of intravenous (IV), intramassetric (IM) submucosal (SM) routes & oral routes of dexamethasone administration post impacted third molar removal surgery. Type of Study: Prospective randomized comparative clinical study. Materials and Method: This prospective comparative study included 60 patients with Class II and position B type of impaction (according to Pell and Gregory's classification). Patients were randomly divided into 4 groups. Group A, B, C & D patients received 8mg dexamethasone immediately post-surgical tooth removal via the IV, SM and IM route & oral respectively. Assessment of swelling, mouth opening and pain was done at intervals of 1st, 3rd and 7th post-op days. Results: The average age of the patients was 27 years. The mean time taken was 20 mins 40 seconds. The IV group showed minimal swelling and better pain control on the 3rd post op day (statistically significant). All 4 routes showed comparable mouth opening results. Conclusion: IV administration of dexamethasone post third molar surgery has been the traditional way because of its faster onset of action and increased efficacy; IM and SM routes are also comparably effective although oral route had the best patient acceptance.

AimThe aim was to evaluate the impact of intermittent fasting (IF) on human body mass index (BMI) and serum lipid profile thorough constructive rectification of gut microbiota.Methods and resultsFourteen healthy women and thirty-one men were included in the study. Their blood and fecal samples were collected before and at the end of the study. Blood parameters, anthropometric values, and gut microbiology were noted to investigate the impact of intermittent fasting (IF) on human gut microbiota and physiology. Our data revealed that IF reduces the body weight and improves blood lipid profile, such as increasing high-density lipoprotein (HDL) and decreasing total cholesterol, triglycerides, and low- and very low-density lipoprotein levels. IF also decreases culturable aerobic bacterial count and increased fungal count. It was also found that the gut metagenome is altered considerably after IF. The human fecal bacterial diversity exhibited significant changes in decreased overall bacterial population, increased bacterial diversity (alpha diversity), and promoted evenness within the bacterial population at the species level. Anti-inflammatory bacteria Lactobacillus and Bifidobacterium were favorably increased, while pathogenic bacteria were decreased.ConclusionCollectively, these results indicated that IF could improve lipid profile and body weight in humans, and the potential mechanisms might be via regulating gut microbiota.Significance and impact of the studyWe demonstrated for the first time that IF improved body weight and blood lipid profile, indicating that IF could mitigate gut microbiota in humans.

The aim of the study is to compare the efficacy of intravenous (IV), intramassetric (IM), and submucosal (SM) routes of dexamethasone administration post-impacted third molar removal surgery. Materials and Methods: This prospective comparative study included 45 patients with Class II and position B type of impaction (according to Pell and Gregory's classification). Patients were randomly divided into three groups. Group A, B, C patients received 8mg dexamethasone immediately post-surgical tooth removal through the IV, SM, and IM route, respectively. Assessment of swelling, mouth opening, and pain was done at intervals of 1 st , 3 rd , and 7 th post-operative days. Results: The average age of the patients was 27 years. The average time taken was 20 min 40 s. The IV group showed minimal swelling and better pain control on the 3 rd post-operative day (statistically significant). All three routes showed comparable mouth opening results. Conclusion: IV administration of dexamethasone post-third molar surgery has been the traditional way because of its faster onset of action and increased efficacy; the IM and SM routes are also comparably effective and have their own advantages.

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