Despite strenuous studies since the last century, the precise cause and pathology of schizophrenia are still largely unclear and arguably controversial. Although many hypotheses have been proposed to explain the etiology of schizophrenia, the definitive genes or core pathological mechanism remains absent. Among these hypotheses, however, GABAergic dysfunction stands out as a common feature consistently reported in schizophrenia, albeit a satisfactory mechanism that could be exploited for therapeutic purpose has not been developed yet. This review is focusing on the progress made to date in the field in terms of understanding the mechanisms involving dysfunctional GABAergic system and loops identified in schizophrenia research.

The current study was aimed to assess the reliability and validity of the Urdu version of the Psychosomatic Symptoms Scale (PSSS) in Pakistani patients. The PSSS is time-saving and easy to administer. The field experts drafted the translated version of PSSS. The Urdu version of PSSS, Patient Health Questionnaire- 9 (PHQ-9), and Symptom Checklist-90 (SCL-90) Urdu version were used for assessment. The translation procedure was comprised of three steps, namely forward translation, back translation, and expert panel discussion. A sample of 982 (men = 50.5% and women = 49.5%) was collected with a convenient sample technique from a general hospital and private clinic. The Cronbach’s alpha for PSSS was 0.974. The confirmatory factor analysis (CFA) revealed that all the items factor loading of PSSS were more than 0.35, the root mean square error of approximation (RMSEA) was = 0.062, the standardized root mean residual (SRMR) was = 0.043, and the comparative fit index (CFI) was = 0.97 with 90% CI. The results also showed that women (M = 72.08, SD = 6.79) are more likely to have psychosomatic symptoms than men (M = 51.21, SD = 13.36) on P < 0.001. The PSSS Urdu version is proven to be a useful and reliable instrument for screening, monitoring, and assessing Pakistani patients’ psychosomatics symptoms.

The long interspersed nuclear elements 1 (LINE-1/L1s) are the only active autonomous retrotransposons found in humans which can integrate anywhere in the human genome. They can expand the genome and thus bring good or bad effects to the host cells which really depends on their integration site and associated polymorphism. LINE-1 retrotransposition has been found participating in various neurological disorders such as autism spectrum disorder, Alzheimer’s disease, major depression disorder, post-traumatic stress disorder and schizophrenia. Despite the recent progress, the roles and pathological mechanism of LINE-1 retrotransposition in schizophrenia and its heritable risks, particularly, contribution to “missing heritability” are yet to be determined. Therefore, this review focuses on the potentially etiological roles of L1s in the development of schizophrenia, possible therapeutic choices and unaddressed questions in order to shed lights on the future research.

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