No abstract

There are only 22 pharmaceutical companies out of 151 in Bangladesh producing quality product maintaining the cGMP, where mor e than 40 companies manufacturing Losartan Potassium 50 mg tablets. So, the clinicians and pharmacists are facing difficulty to choose a suitable brand or alternative use. The aim of the present study was to predict the bioequivalence of four top ranked brands of Losartan Potassium tablets marketed in Bangladesh using In Vitro tests. The In Vitro dissolution study was carried out with the five brands of 50 mg Losartan Potassium tablets according to FDA dissolution method. The process was done for 12 tablets of each brand; using 900 ml of pH 1.2 0.1 N HCl, pH 4.5 Acetate Buffer, pH 6.8 Phosphate Buffer and water separately as dissolution media; 50 rpm as rotation speed; 37°C ± 0.5°C as media temperature; 10, 15, 20, 30, 45 and 60minutes as sample collection time points. The results were carried out by interpreting data on the equations of Dissolutio n Efficiency (DE), Difference Factor (f1), Similarity Factor (f2). There were significant differences in the dissolution profiles of the five brands specially when considered according to different media. In pH 1.2 0.1 N HCl all brands showed poor drug release but most were close to innovator brand, but in pH 4.5 Acetate Buffer was unlike due to decrease of ionic strength by media, which affect preferably to innovator brand. pH 6.8 Phosphate Bu ffer and water gave best results for drug release of most of the brands and proved reliable to claim RRR, SSS and NNN as bioequivalent and interchangeable with each other as well as with the innovator brand. The BBB showed poor dissolution profile, which will likely result in poor bioavailability. The results show the need for constant monitoring of new brands of Losartan Potassium introduced into the drug market to ascertain bioequivalence and conformity with pharmacopoeia standards.

Consumption of takeaway and fast food by young adolescents is no longer confined to the developed countries; it has spread to the developing countries as well. The culture of fast food consumption has replaced the traditional meal among university students and is a great public health concern. Excessive consumption of fast food is responsible for obesity epidemics and the cause of a dramatic increase of obesity-related diseases. A cross-sectional study was carried out from March to December, 2015 among students attending in five

Aims: The present study was planned to assess the sedative and anxiolytic efficacy of Amaranthaus tricolor L methanolic extract in vivo. Place and Duration of Study: Department of Pharmacy, between January 2018 and August 2018. Methodology: In this experiment, the crude extract of Amaranthus tricolor L. was evaluated for its CNS depressant effect using rodent behavioral models, such as open field, hole cross and rota rod tests for its sedative properties and an elevated plus maze test for its anxiolytic potential, respectively. Results: In sedative assay, a dose-dependent and statistically significant (p<0.05) suppression of locomotors activity of the mice in both open field and hole cross test was exhibited by theextract at a dose of 200 and 400 mg/kg body weight. The extract also displayed increased percentage of entry into open arms at both doses in anxiolytic potential study. At a dose of 400 mg/kg body weight significant anxiolytic activity (p<0.05) was found compared to the standard diazepam. Conclusion: The pivotal CNS depressant and anxiolytic activity of the methanolic extract of Amaranthus tricolor L leaves was discovered in this experiment. Further research on the extract's biologically active phytochemicals may provide access to therapeutic intervention.

Cardiovascular disease, and ischemic heart disease (IHD), is a major cause of morbidity and mortality in the very elderly patients worldwide. These patients represent a rapidly growing cohort presenting for percutaneous coronary intervention (PCI), now constituting more than one in five patients treated with PCI in real-world practice. From July 2020 we included 152 patients with IHD purposively in Cardiology department of Bangabandhu Sheikh Mujib