Mini-Percutaneous Nephrolithotomy (Mini-PCNL) and Retrograde intra-renal surgery (RIRS), can be carried out in a single stage or numerous phases depending on the burden, size, and/or location of the stone. Objective: To check the efficacy of Mini-Percutaneous Nephrolithotomy and Retrograde intra-renal surgery on adult patients with a renal stones. Methods: A total of 101 patients were included who underwent RIRS (n=51) or mini-PCNL (n=50) at Doctors Hospital Jail Chowk in Gujrat, Pakistan in 2021. Retrospective observations were made on 101 individuals who received RIRS or mini-PCNL. Results: The mean hospital stay time was significantly lower in RIRS group i.e., 01.81 ± 0.59 days as compared to mini-PCNL group (p value <0.001). The operation time was 63.72 ± 14.94 minutes for mini-PCNL and 72.65 ± 15.83 minutes for RIRS group. The stone clearance rate was 92% in mini-PCNL group and 82.35% in RIRS group. Conclusions: In conclusion, we found that both mini-PCNL and RIRS are safe and effective ways to treat renal calculi. RIRS is a non-invasive, practical therapeutic option with reduced hospitalizations times, morbidity, and complication rates for these individuals.

Kidney stones, also known as renal calculi, are crystal concretions that primarily occur in the kidney and are referred to as nephrolithiasis. Ideally, calculi should form in the kidneys and pass out of the body through the urethra painlessly. Larger stones are uncomfortable and thus require surgery. Mini-percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS) are the minimally invasive procedures employed these days to target renal stones. Objective: To compare the effectiveness of both mini-PCNL and RIRS in terms of targeting larger stones in adult patients along with other factors including hospital stay, operative time, stone passing rate and associated complications. Patients and Methods: In the year 2021, 101 patients undergoing mini-PCNL or RIRS in Doctors Hospital, Gujrat were observed in this study. Effectiveness of both the techniques, exposure time, transfusions required, stone free rates and hospital stay were compared in both groups of patients. Results: It was found that mini-PCNL has greater potential than RIRS in terms of stone clearing and operating time. However, RIRS has performed better in terms of reducing the hospital stay with mild complications in both the procedures. Conclusion: Both RIRS and mini-PCNL are extremely safe and highly efficient treatments for renal lithiasis with a diameter of 1.5 to 2.5 cm, and either one can be chosen to achieve outstanding stone-free rates.