Objective: The purpose of this study was to compare the HRQoL of patients who had complete revascularization at the time of the first admission to those who underwent revascularization of the infarct artery alone using the EQ-5D (European quality of life-5 dimensions) self-report questionnaire. Background: The effect of revascularization procedures on health-related quality of life (HRQoL) in patients with multivessel disease who undergo primary percutaneous coronary intervention is the subject of controversy (P-PCI). Methods and Results: There was a significant difference between individuals with STEMI who received revascularization of the infarct-related artery alone and those who got total revascularization. we divided the group by the extent of complete revascularization (n=147) or the extent of IRA-only revascularization (n = 153) during the index admission Mobility, self-care, routine activity, pain or discomfort, anxiety, and sadness were all evaluated using the EQ-5D scale. The prevalence of heart failure and the gender of patients were different at baseline. Patients who had full revascularizations had lower mean ±SD (EQ-VAS and EQ-5D) utility ratings than those who had infarct artery revascularizations alone after 2 years of follow-up. (70.00 (±19.9) vs. 51.04 (±17.8), P < 0.04, and 0.71 (±0.03) vs0.61 (±0.03), P<0.005, respectively). Conclusion: Complete revascularization produced clinically significant increases in quality of life when compared to treating just the IRA at 24 months. Keywords: Complete Revascularization, Infarct-related artery, Primary percutaneous coronary angioplasty, ST-segment elevation.

OBJECTIVE: To describe conventional risk factors by age and gender in coronary artery diseasepatients.MATERIALS AND METHODS: This study was conducted in outdoor patient department of agencyheadquarter hospital (AHQ) Landikotal, Khyber agency, from June to October 2013. It was a hospitalbased descriptive observational study. Sample size was 926 patients with established coronary arterydisease, recruited through purposive convenient sampling technique. Adult patients (above 18 years) ofboth genders with coronary artery disease were included in the study. Every patient was evaluated forthe presence of conventional risk factors. Card vascular risk factors were assessed by a self-administeredquestionnaire and various laboratory tests.RESULTS: Total patients were 926, male were 546(59%). Mean age was 58.28±12.005 years (20-95years). Study population was divided into younger (age <40 years) and older age groups (> 40 years).Younger patients were 66(7.1%) and older age 866(92.9%). Hypertension was present in 563 patients(61.1%) with 59.2%and 63.2% in male and female, respectively (p=0.186). Diabetes was present in29.9% with 27.8% in male and 32.9% in female patients (p=0.098).Hypertension was significantly morecommon in older patients while smoking and heavy fat intake was significantly more common inyounger patients. Other risk factors for CAD were similar across younger and older age groups.CONCLUSION: Conventional risk factor in male and female differ widely with smoking, ex-smoker,heavy fat intake and obesity is significantly more common in male patients, while family history forCAD is common in female patients. Diabetes is higher in 40 years or above patients while smoking ishigher in patients less than 40 years.KEY WORDS: Conventional Risk Factor, Coronary Artery Disease, Age, Gender

Background: Treatment delay is considered to be one of the important predictors of survival in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). We investigated the impact of early successful PPCI for STEMI patients on left ventricular ejection fraction. Methodology: This prospective study was carried out on 50 patients having STEMI undergoing PPCI in NICVD Karachi. Patients were divided into two groups, Group A, early presenter, patients received treatment with PPCI within six hours of the onset of symptoms, and group B, late presenter, patients received treatment after six hours up to twenty-four hours of the onset of symptoms. Results: Group A patients showed promising results, having achieved TIMI grade III flow in 100%, whereas 85% of patients achieved TIMI grade III flow in group B (P = 0.02). There was a statistical difference between the two groups. Using Independent sample T-Test Group A patients showed improved LVEF as compared to Group B (at presentation 45.49±3.99% vs. 35.25±3.85%; P = 0.001 and at 3 months follow up 55.66±0.92% vs. 45.75±1.44%; P = 0.001). Conclusion: Early PPCI treatment of STEMI patients can lead to improved TIMI grade flow and LVEF. Efforts must be made to shorten the delay in reperfusion therapy.