Rational design for a new spiroxindoles, combined with a benzimidazole scaffold to identify a new murine double minute two (MDM2) inhibitor was synthesized and characterized. The desired spiroxindoles were achieved via a [3+2] cycloaddition reaction approach which afforded the cycloadducts with four asymmetric centers separated in an excellent regioselective and diastereoselective compound. The separated spiroxindoles were subjected to a set of biochemical assays including an NCI cell panel assay, MTT assay, and MDM2 binding analysis by a microscale thermophoresis assay. The anticancer reactivity for the tested compounds showed IC50 (µM) in the range between 3.797–6.879 µM, and compound 7d with IC50 = 3.797 ± 0.205 µM was the most active candidate between the series. The results showed promising results that identified that compound 7a could be inhibited the MDM2 with KD = 2.38 μm. Compound 7a developed a network of interactions with the MDM2 receptor studied in silico by molecular docking.

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In the recent past, gender issues have grabbed substantial attention from social scientists, activists and academic fraternity. Right from family to workplace to society at large, attempts have been initiated to advocate equal rights for women in different spheres of life. Despite social activists and policy makers striving hard towards gender sensitization, gender discrimination still persists in various domains of life. Therefore, there is a strong need to identify the factors that potentially determine people’s attitude towards gender equity. With this very objective, the current study examines existing literature on gender discrimination and its association with Hofstede’s (1980) cultural values. Following the “Gender-Organization-System Approach”, the present study postulates that gender equality or inequality results from a complex interaction of individual, organizational and societal factors and that it cannot be explained in isolation from the broader socio-cultural milieu. Extensive review of literature indicates that cultural values are significant predictors of people’s attitude towards gender equity and that the extent to which people conform to existing gender roles determine how much people support the idea of gender equality. The study has significant practical implications since, by means of detecting such “causal factors”, more positive attitudinal changes can be brought about and gender egalitarian attitudes can be cultivated.

Rapid increase in automobile density and discharge of different types of pollutants from automobile are a serious issue for whole civilized world and in Bhakkar also.Vehicle emission from automobiles released an enormous quantity of toxic pollutants likewise nitrogen dioxide, sulfur dioxide, carbon mono oxide, heavy metals particularly lead, cadmium in environment and produced harmful effects on germination and growth of plants. This study was aim to investigate the effect of automobile polluted soil on the growth of some tree species. In present study the variation in seedling growth performance of three different selected tree species namely, Acacia nilotica L., Albizia lebbeck L. (Benth.) and Eucalyptus globulus Labill. raised in roadside polluted soils of District Bhakkar, Pakistan were recorded in the pots. Results showed that root, shoot, seedling length, number of leaves, and seedling dry weight of Acacia nilotica grown in polluted road soils of Bhakkar-Khansar road showed a significant (p<0.05) decline. Statistical analysis of recorded data showed that root growth and leaf area of Albizia lebbeck in the soil of Bhakkar-Khansar road soil significantly (p<0.05) decreased as compared to control. Similarly, a significant (p<0.05) reduction in shoot, seedling length, number of leaves, leaf area and seedling dry weight performance of E. globulus in polluted soils of Bhakkar-Notak was recorded.