Background and objective Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result. Methods Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT. Results Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% CI 52.18–100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease. Conclusion This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.

This study attempt to examine the risk reduction mechanism of the COVID-19 outbreak in Pakistan. World Health Organization (WHO) declared the emergency and provided guidelines to reduce the risk of a pandemic. Thus, people tried to adopt multiple health safety measures to reduce the risk of a pandemic outbreak. Therefore, this study was designed to conduct an online survey technique to collect information from 1264 individuals in Pakistan. The rationale to select the technique was based on the pandemic situations in the country i.e. COVID-19. Moreover, it was used to main social distancing and following the health safety measures. Thus, a well-structured questionnaire was administered based on an attitudinal scale and google form was used. The inclusion criteria were defined on the questionnaire such as an independent age bracket (18-60), resident of Pakistan, using social media, and literate. The response was stopped after reaching the sample at 1264 participants. The study findings reveal that social isolation, social distancing, and the use of personal protective equipment (PPE) had a significant positive impact on risk reduction of COVID-19 among individuals. Moreover, hand and respiratory hygienic along with the risk of infection also significantly contributing to minimizing the pandemic outbreak.

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Aim: To determine the prevalence, attitude, and knowledge of self-medication of general population for the prevention of coronavirus during the COVID 19 pandemic. Place and duration of the study: Major studies of Punjab during 2020. Methodology: A self-generated questionnaire was distributed online amongst the general population of Punjab excluding the people using medication for any other chronic medical disorder. The study included the general public including the age group from 16-60 years. Results: Among 290 participants, 33.7% were males and 66.3% were female. Based on the data obtained 53% used medication without a doctor’s prescription (self- medication) while 46.7% took the medication with a doctor’s prescription. Those with the habit of self-medication relied on both allopathic and herbal medications due to various reasons, the most frequent reason found was unavailability of doctors (27.8%). The most frequently used self-medicated drugs were pain killers, Hydroxychloroquinone, Azithromycin and Ivermectin to prevent from this deadly virus (p-value=0.000).Adverse effects reported after self-medications are statistically non-significant. Conclusion It is concluded that majority of the general population of Punjab are in the habit of self-medicating themselves because of difficulty in approaching physicians and the most commonly self-medicated drug with or without symptoms was found to be tablet Azithromycin as a preventive measure during this pandemic. Keywords: COVID-19, self-medication, adverse effects

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