Background: Migraine is defined as a condition accompanied with head ache, nausea, visual and sound sensitivity. Objective: To determine the effect of migraine on maternal and neonatal health. Study Design: Case control study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st August 2018 to 31st August 2021. Methodology: One hundred pregnant women divided into migraine and non-migraine groups were enrolled. Both groups were assessed for their sociodemographic, clinical and biochemical status. Their information was documented. Results: Group I females were above 36 years of age and were in their first trimester. There were 56% women who did not presented visual aura. More irritability, pre-term labour and preeclampsia, risk of C section and hypertension was noticed in group I than Group II. Conclusion: Migraine is linked with higher risk of hypertension, preeclampsia, C section and low birth weight new born. Key words: Migraine, Pregnancy, Low birth weight

Background: Pregnancy induced hypertension is a fetal disease resulting into morbidity and mortality of female as well as its neonate. Objective: To find the incidence of pregnancy induced hypertension in Pakistani women. Study Design: Cross sectional study Place and Duration of the Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta from 1st March 2019 to 31st March 2021. Methodology: Seven hundred and twenty eight females were identified with pregnancy induced hypertension from all the pregnant women attending the outdoor were enrolled. Each female was checked for their protein urea as well as systolic and diastolic blood pressure according to standard operating protocol. Socio-demographic, clinical and family history were documented. Results: Among all pregnant women, 150 were identified as pregnancy induced hypertensive with a 20.6% incidence of pregnancy induced hypertension. The mean value systolic blood pressure value was 144.3±5.2 and of diastolic as 83.1±5.2 in pregnancy induced hypertension women. Conclusion: Family history, obesity and renal diseases are the main factors associated with pregnancy induced hypertension with an incidence of 20.6% among pregnant women. Keywords: Pregnancy induced hypertension, Body mass index, Pregnant women, Hypertension

Background: Dengue infection has been observed to cause critical outcomes in mother as well as child from an infected pregnancy. Objective: To assess the maternal and neonatal outcomes of dengue infected pregnancy. Study Design: Prospective study. Place and Duration of Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta 1st August 2018 to 28th February 2021. Methodology: Fifty pregnant females were enrolled after their dengue confirmation either by NS1, IgM or IgG test. Clinical and demographic information was recorded. Pregnancy and neonatal outcomes were noticed by following the patients until delivery and postpartum period and the new born if infected then up to post 6 months of delivery. Results: The mean age of patients was 25.5±3.5 years. Out of the total pregnant dengue infected females 60% had multigravida. Fifty percent of females came for clinical assistance in their third trimester. Post-partum hemorrhages were common in 6% patients. Vertical transmission was seen in three cases where two did not survive and had intra uterine death. Maternal mortality was seen in 14% of total cases. Conclusion: Morbidity, preterm labor, vertical transmission, intrauterine death are some of the maternal and neonatal outcomes of dengue infected pregnancy. Keywords: Dengue, Pregnancy, Neonatal outcomes, Maternal outcomes

Background: Rubella is major cause of neonatal abnormalities and miscarriages on worldwide level. Objective: To find the incidence of rubella in congenital births by assessing antibodies against rubella. Study Design: Cross sectional study Place and Duration of Study: Department of Obstetrics & Gynaecology, Sandeman Provincial Hospital, Quetta 1st April 2019 to 31st March 2021. Methodology: Four hundred pregnant women were analyzed for their IgG and IgM levels. A complete socioeconomic, demographics and clinical information was recorded on a well designed questionnaire. Results: The mean age of pregnant women was 24.5±4.1 years. Majority of women were between 35-40 years. High IgG were seen in all patients compared with IgM. The seropositivity for IgG increased with increasing age. Conclusion: The total reported IgG positive cases were up to 16% while of IgM were 3%. Keywords: Rubella, Pregnancy, Birth defects