No abstract

In recent years, scientific advancements have constantly increased at a significant rate in the field of biomedical science. Keeping this in view, the application of porphyrins and metalloporphyrins in the field of biomedical science is gaining substantial importance. Porphyrins are the most widely studied tetrapyrrole-based compounds because of their important roles in vital biological processes. The cavity of porphyrins containing four pyrrolic nitrogens is well suited for the binding majority of metal ions to form metalloporphyrins. Porphyrins and metalloporphyrins possess peculiar photochemical, photophysical, and photoredox properties which are tunable through structural modifications. Their beneficial photophysical properties, such as the long wavelength of emission and absorption, high singlet oxygen quantum yield, and low in vivo toxicity, have drawn scientists’ interest to discover new dimensions in the biomedical field. Applications of porphyrins and metalloporphyrins have been pursued in the perspective of contrast agents for magnetic resonance imaging (MRI), photodynamic therapy (PDT) of cancer, bio-imaging, and other biomedical applications. This review discusses photophysics and the photochemistry of porphyrins and their metal complexes. Secondly, it explains the current developments and mode of action for contrast agents for MRI. Moreover, the application of porphyrin and metalloporphyrin-based molecules as a photosensitizer in PDT of cancer, the mechanism of the generation of reactive oxygen species (ROS), factors that determine the efficiency of PDT, and the developments to improve this technology are delineated. The last part explores the most recent research and developments on metalloporphyrin-based materials in bio-imaging, drug delivery, and the determination of ferrochelatase in bone marrow indicating their prospective clinical applications.

No abstract

PurposeThe purpose of this study is to investigate the impact of technology orientation (TO) on firm performance (FP). This study also aims to identify the mediating role of firm innovativeness (FI) in the relation between TO and FP.Design/methodology/approachQuantitative approach has been adopted for analyzing the impact of TO on FP in software houses located in two big cities of Pakistan. Mean, standard deviation, correlation and regression analysis were used.FindingsResults proved that of TO predicts FP and FI mediate the relationship between TO and FP.Practical implicationsThis study used cross-sectional further studies may be conducted using longitudinal research design for achieving in-depth insights.Social implicationsSoftware houses should focus on TO and innovativeness for improving their performance.Originality/valueThis research guides the way to improve performance TO and innovativeness of software houses based on the empirical results.

No abstract