Cotton fibre is one of the most important commodity fibre and is widely employed in apparels. At present, the share of natural fibres in production of nonwoven fabrics is low and employed in opt applications. The cotton fibre is conventionally converted into woven and knitted fabrics by short staple spinning methods. The comber noil is short fibre waste during production of combed cotton yarns. The aims of the current study were to employ comber noil for preparation of hydroentangled cotton nonwovens at varying water jet pressures and conveyor speeds. The effect of these parameters is studied with respect to mechanical and comfort properties of prepared fabrics. The results showed that these variables can help to manufacture fibrous assemblies with engineered properties according to required application area.