Mango sudden death (MSD) or quick decline (QD) is the most destructive disease found in mango orchards of Pakistan and is characterized by collapse of the vascular system by Ceratocystis fimbriata and Lasiodiplodia theobromae. Cultural practices, chemicals, and biological control are the most valuable tools for the management of MSD, but the role of micronutrient deficiencies has remained an area that is heavily ignored by the farming community. To study the impact of micronutrients, four mango orchards were selected at different locations where different combinations of micronutrients, i.e., Zinc (Zn), Boran (B), and Copper (Cu) in the form of Zinc sulphate (ZnSO4), Borax/Boric acid (H3BO3), and Copper Sulphate (CuSO4), were applied both foliar and in drench along with the recommended doses of Nitrogen: Phosphorous: Potassium (NPK), and Farmyard manure (FYM), respectively. The quantities of micronutrients were determined from the soil and leaves before and after application of the treatments. The impact of micronutrients was measured in terms of reduction in disease severity and increase in fruit yield. The results revealed that the application of all three micronutrients both in soil drench and in foliar form significantly decreased the disease severity at three locations and increased the yield in all four mango orchards. Application of ZnSO4 (0.8%), +H3BO3 (0.8%), +CuSO4 (0.5%) and as soil drench ZnSO4 (400 g) + Borax (200 g) + CuSO4 200 g plant−1 proved to be the best treatments, with an average of 12.88 and 14.03% reduction in disease severity and with an average yield of 128 and 119 kg, respectively. The application of micronutrients would be a promising solution in an integrated disease management program used to tackle MSD.