No abstract

Bu çalışmada, hastanede yatan süt çocuğu hastalarında, kesinleşmiş tanılar ile Creaktif protein (CRP) düzeylerinin karşılaştırılması ve CRP'nin bakteriyel enfeksiyon tanısında güvenilir bir belirteç olup olmadığının incelenmesi amaçlandı. Materyal ve metot: Yaşları bir-24 ay arası değişen 192 hastanın dosyaları geriye dönük olarak incelendi. Olguların yaş, cinsiyet ve tanı gibi demografik verileri ile lökosit, lenfosit, nötrofil, trombosit sayıları, hemoglobin, CRP düzeyleri ve eğer alınmışsa akciğer grafisi raporları, tam idrar tahlili, idrar kültürü, gayta mikroskopisi, gayta kültrü, kan kültürü, beyin omurilik sıvısı (BOS) mikroskopisi ve BOS kültürü sonuçları kaydedildi. Bulgular: Olguların 83'ü (% 43,2) kız ve 109'u (% 56,8) erkek idi. Olguların 78'i (% 40,6) bakteriyel enfeksiyon tanısı alırken, 114'ü (% 59,4) viral enfeksiyon tanısı aldı. Bakteriyel enfeksiyon grubunda ortalama CRP düzeyleri 1,94±3,28 mg/dl iken viral enfeksiyon grubunda 1,13±1,51 mg/dl idi (p = 0,001). İki grup arasında istatistiksel olarak anlamlı fark saptandı. ROC analizinde CRP'nin bakteriyel enfeksiyon saptamadaki duyarlılığı % 60,26, özgüllüğü % 45,61 (AUC [%95 Cl] 0,534 ve p = 0,429), pozitif öngörücü değeri % 43,09 ve negatif öngörücü değeri % 62,67 olarak hesaplandı. Sonuç: CRP değerlerinin bakteriyel enfeksiyonlarda viral enfeksiyonlara göre anlamlı düzeyde arttığı ancak bakteriyel enfeksiyonu viral enfeksiyondan ayırt etmedeki duyarlılık ve özgüllüğünün zayıf olduğu gözlendi.

Background The aim of this study was to determine the predictive risk factors for development of severe bronchiolitis in patients with acute bronchiolitis with no previous chronic disease. Methods Four hundred forty children aged 1‐24 months hospitalised with acute bronchiolitis, were examined between February 2018 and February 2019 in this prospective study. Results Eighty‐five cases were regarded as severe bronchiolitis and 355 as mild‐moderate bronchiolitis. Statistically significant differences were observed between the severe and mild‐moderate bronchiolitis groups in terms of weight‐for‐age z‐scores, history of bronchiolitis, haemoglobin levels, and time elapsed between the onset of symptoms and admission. Weight‐for‐age z‐scores, the mean time interval between the onset of symptoms and admission, and mean haemoglobin values were lower in the severe bronchiolitis group while the mean number of bronchiolitis attacks was higher than in the mild‐moderate bronchiolitis group. Logistic regression analysis determined that a low weight‐for‐age z‐score increased the risk of severe bronchiolitis development 0.56‐fold (CI: 0.409‐0.760), a short duration between the onset of symptoms and admission increased the risk 0.62‐fold (CI: 0.519‐0.735), a frequent history of bronchiolitis increased the risk 1.81‐fold (CI: 1.135‐2.968) and low haemoglobin levels increased the risk 0.72‐fold (CI: 0.537‐0.969). Conclusion Low weight‐for‐age z‐scores, a short duration between the onset of symptoms and admission, a high number of previous attacks and low haemoglobin levels were identified as independent parameters of severe bronchiolitis development.

No abstract

Background: The aim of this study was to determine the predictive risk factors for development of severe bronchiolitis in patients with acute bronchiolitis with no previous chronic disease. Methods: Four hundred forty children aged 1-24 months hospitalized with acute bronchiolitis, were examined between February 2018 and February 2019 in this prospective study. Results: Eighty-five cases were regarded as severe bronchiolitis and 355 as mild-moderate bronchiolitis. Statistically significant differences were observed between the severe and mild-moderate bronchiolitis groups in terms of weight-for-age z-scores, history of bronchiolitis, hemoglobin levels, and time elapsed between onset of symptoms and admission. Weight-for-age z-scores, the mean time interval between onset of symptoms and admission, and mean hemoglobin values were lower in the severe bronchiolitis group while the mean number of bronchiolitis attacks was higher than in the mild-moderate bronchiolitis group. Logistic regression analysis determined that a low weight-for-age z-score increased the risk of severe bronchiolitis development 0.56-fold (CI: 0.409 – 0.760), a short duration between the onset of symptoms and admission increased the risk 0.62-fold (CI: 0.519 – 0.735), a frequent history of bronchiolitis increased the risk 1.81-fold (CI: 1.135 – 2.968) and low hemoglobin levels increased the risk 0.72-fold (CI: 0.537 – 0.969). Conclusion: Low weight-for-age z-scores, a short duration between the onset of symptoms and admission, a high number of previous attacks, and low hemoglobin levels were identified as independent parameters of severe bronchiolitis development. Key words: Bronchiolitis, Infant, Risk factors, Severity degree