Nitrogen-comprising heterocyclic compounds and their derivatives have empirically been invaluable as therapeutic agents. Fundamentally, 4-chloro-6-nitro-2-amino-1,3-benzothiazole 1 was synthesized via bromination of 2-chloro-4-nitro aniline with ammonium thiocyanate. This new heterocyclic haloorganoamino-1,3-benzothiazole derivative, was a starting material, which condensed and tethered with three different aromatic aldehyde pendant arm in presence of ethanol and glacial acetic acid isolating an interesting sequence of tridentate Schiff bases 2-4. These compounds were used for complexation reactions in 1:1 (metal: ligand) stoichiometry to obtain heteroleptic Al(III), Ni (II) and K(I) benzothiazole chelates 5-7(a-c) of the type [Al(L)Cl 2 , Ni(L)Cl, K(L) {L = Schiff base derivatives}]. The newly synthesized complexes were characterized by the melting points, IR and some of them by 1 H-NMR spectroscopy and only one by X-ray techniques. The structures of complexes were anticipated from the spectroscopic studies.

The present work involves study of some new 1,3-oxazepine and diazepines derivatives by cycloaddition reaction between Schiff s bases and (Succinic imide, phthalic imide, and 3-nitophthalic) anhydride with dry benzene as a solvent. Oxazepine and diazepines derivatives from 4-chloro-6-nitrobenzo[d]thiazol-2-amine were synthesized. These derivatives were synthesized by the reaction of Schiff base with different anhydrides in presence of dry benzene. The starting material was 4-Chloro-6-nitro 2-aminobenzothiazole which prepared from 2-Chloro -4-nitroaniline and ammonium thiocyanate with presence of bromine and sodium acetate. The prepared compounds have been characterized by melting points and some physical properties besides the FT-IR,H-NMR spectra. The purity for these compounds was checked by TLC.

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New compounds of (E-(1,3-bis)prop-2-en-1-one] have been synthesized. The prepared compounds have synthesized from chalcone [1] and characterized by using FT-IR, Uv/ vis and 1 H-NMR spectra besides, determining the melting points and Rf with the biological activity.