In this paper, a noise-resistant image encryption scheme is proposed. We have used a cubic-logistic map, Discrete Wavelet Transform (DWT), and bit-plane extraction method to encrypt the medical images at the bit-level rather than pixel-level. The proposed work is divided into three sections; In the first and the last section, the image is encrypted in the spatial domain. While the middle section of the proposed algorithm is devoted to the frequency domain encryption in which DWT is incorporated. As the frequency domain encryption section is a sandwich between the two spatial domain encryption sections, we called it a "sandwich encryption." The proposed algorithm is lossless because it can decrypt the exact pixel values of an image. Along with this, we have also gauge the proposed scheme's performance using statistical analysis such as entropy, correlation, and contrast. The entropy values of the cipher images generated from the proposed encryption scheme are more remarkable than 7.99, while correlation values are very close to zero. Furthermore, the number of pixel change rate (NPCR) and unified average change intensity (UACI) for the proposed encryption scheme is higher than 99.4% and 33, respectively. We have also tested the proposed algorithm by performing attacks such as cropping and noise attacks on enciphered images, and we found that the proposed algorithm can decrypt the plaintext image with little loss of information, but the content of the original image is visible.INDEX TERMS Discrete Wavelet Transform (DWT), Chaotic map, Medical images, Bit-plane decomposition, Security analysis of medical images.

The advancement in wireless communication has encouraged the process of data transferring through the Internet. The process of data sharing via the Internet is prone to several attacks. The sensitive information can be protected from hackers with the help of a process called Encryption. Owing to the increase in cyberattacks, encryption has become a vital component of modern-day communication. In this article, an image encryption algorithm is suggested using dynamic substitution and chaotic systems. The suggested scheme is based upon the chaotic logistic map, chaotic sine maps and the dynamical substitution boxes (S-boxes). In the proposed scheme, the S-box selection is according to the generated sequence by deploying the chaotic sine map. To evaluate the robustness and security of the proposed encryption scheme, different security analysis like correlation analysis, information entropy, energy, histogram investigation, and mean square error are performed. The keyspace and entropy values of the enciphered images generated through the proposed encryption scheme are over 2 278 and 7.99 respectively. Moreover, the correlation values are closer to zero after comparison with the other existing schemes. The unified average change intensity (UACI) and the number of pixel change rate (NPCR) for the suggested scheme are greater than 33, 99.50% respectively. The simulation outcomes and the balancing with state-of-the-art algorithms justify the security and efficiency of the suggested scheme.

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Background: Cyclosporine A (CsA) is an exceptional immunosuppressant used for the treatment of immune disorders. Niosomal vesicles are promising drug carriers that are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. The objective of the study was to formulate combined nonionic surfactant based vesicles and to evaluate their in vitro characterization, release studies and in vivo studies. Materials and Methods: Five niosomal formulations (F 7 to F 11) were prepared using the thin film hydration method. The molar ratio of cholesterol and non-ionic surfactant taken was 1:1. In formulation F 10 , the combination of surfactants Span 20 and Brij 35 was used. The niosomes were characterized by zeta sizer and SEM for particle size analysis, in vitro drug release and stability studies. The pharmacokinetic studies were conducted on healthy albino rabbits. Results: The size of niosome was found in the range of 427.1 nm to 972.3 nm. SEM image of optimized formulations F 10 exhibit the spherical nature of niosomal vesicles. DSC thermograms of niosomal formulations exhibited a broadened endothermic peak. The stability study exhibited that all formulations are stable and negligible change of vesicle size and entrapment was observed with time. The percentage drug release was significantly higher as compared to CsA plain dispersion for all niosomal formulations at pH 1.2 and 7.4. The release kinetic behavior showed that all preparations were best described by zero order and can release active ingredient in a sustained manner. The pharmacokinetic data showed the test formulation (F10) possessed greater bioavailability as compared to the reference formulation (CsA aqueous dispersion). Conclusion: The formulation F 10 demonstrated a comparatively more delayed rate of release with enhanced dissolution as compared to a single surfactant scheme. The F 10 formulation can be a remarkable nanotechnology for prolonged delivery of CsA orally with improved dissolution profile and bioavailability.

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