Although mutations of the breast cancer susceptibility gene 1 (BRCA1) may play important roles in breast and prostate cancers, the detailed mechanism linking the functions of BRCA1 to these two hormone-related tumors remains to be elucidated. Here, we report that BRCA1 interacts with androgen receptor (AR) and enhances AR target genes, such as p21 (WAF1/CIP1) , that may result in the increase of androgen-induced cell death in prostate cancer cells. The BRCA1-enhanced AR transactivation can be further induced synergistically with AR coregulators, such as CBP, ARA55, and ARA70. Together, these data suggest that the BRCA1 may function as an AR coregulator and play positive roles in androgeninduced cell death in prostate cancer cells and other androgen͞AR target organs.

Crack is a common form of pavement distress and it carries significant information on the condition of roads. The detection of cracks is essential to perform pavement maintenance and rehabilitation. Many of the highways agencies, in different countries, are still employing conventional, costly and very time consuming techniques which involve direct human intervention and assessment. Although automated recognition has been successfully performed for many pavement distresses, crack detection remains, to this date, a topic where reservations exist. A novel approach to automatically distinguish cracks in digital pavement images is proposed in this paper. The Gabor filter is proven to be a highly potential technique for multidirectional crack detection that was not done previously using the Gabor filter. Image analysis using the Gabor function is directly related to the mammalian visual perception, hence the choice of this method for crack detection. Results reported in this paper concentrate on pavement images with high levels of surface texture that makes crack detection difficult. An initial detection precision of up to 95% has been reported in this paper showing a good promise in the proposed method.

Abstract-With the ever-increasing emphasis on maintaining road assets to a high standard, the need for fast accurate inspection for road distresses is becoming extremely important. Surface distresses on roads are essentially three dimensional (3-D) in nature. Automated visual surveys are the best option available. However, the imaging conditions, in terms of lighting, etc., are very random. For example, the challenge of measuring the volume of the pothole requires a large field of view with a reasonable spatial resolution, whereas microtexture evaluation requires very accurate imaging. Within the two extremes, there is a range of situations that require 3-D imaging. Three-dimensional imaging consists of a number of techniques such as interferometry and depth from focus. Out of these, laser imagers are mainly used for road surface distress inspection. Many other techniques are relatively unknown among the transportation community, and industrial products are rare. The main impetus for this paper is derived from the rarity of 3-D industrial imagers that employ alternative techniques for use in transportation. In addition, the need for this work is also highlighted by a lack of literature that evaluates the relative merits/ demerits of various imaging methods for different distress measurement situations in relation to pavements. This overview will create awareness of available 3-D imaging methods in order to help make a fast initial technology selection and deployment. The review is expected to be helpful for researchers, practicing engineers, and decision makers in transportation engineering.

Recently identified androgen receptor (AR) coactivators were used in this study to determine whether the specificity of sex hormones and antiandrogens could be modulated at the coactivator level. We found that ARA70 is the best coactivator to confer the androgenic activity on 17beta-estradiol. Only ARA70 and ARA55 could increase significantly the androgenic activity of hydroxyflutamide, a widely used antiand rogen for the treatment of prostate cancer. None of the AR coactivators we tested could significantly confer androgenic activity on progesterone and glucocorticoid at their physiological concentrations (1-10nM). We also found that ARA70, ARA55, and ARA54, but not steroid receptor coactivator-1 (SRC-1) and Rb, could significantly enhance the delta5-androstenediol-mediated AR transactivation. Furthermore, in comparing the relative specificity of these coactivators to AR in DU145 cells, our results suggested that ARA70 has a relatively higher specificity and that SRC-1 can enhance almost equally well many other steroid receptors. Finally, our data demonstrated that AR itself and some select AR coactivators such as ARA70 or ARA54 could, respectively, interact with CBP and p300/CBP-associated factors that have histone acetyl-transferase activity for assisting chromatin remodeling. Together, our data suggest that the specificity of sex hormones and antiandrogens can be modulated by some selective AR coactivators. These findings may not only help us to better understand the specificity of the sex hormones and antiandrogens, but also facilitate the development of better antiandrogens to fight the androgen-related diseases, such as prostate cancer.

No abstract