ObjectiveNigella sativa (N. sativa) has several pharmacological actions which include antioxidant, antidiabetic, anticancer, antitussive, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, and bronchodilator. The purpose of this study is to measure the effectivity of N. sativa ethanol extract as anti-inflammation on peritoneal Wistar rat mast cells. The laboratory experiment was used to investigate the effectivity of N. sativa as an anti-inflammatory on mast cells. Six groups of mast cells were stimulated by C 48/80 to release histamine. Group 1 were without N. sativa, while group 2, 3, 4, 5, and 6 were given N. sativa with concentrations of 0.1 mg/ml, 0.2 mg/ml, 0.3 mg/ml, 0.4 mg/ml and 0.5 mg/ml, respectively. Histamine concentration was measured by high-performance liquid chromatography-fluorometry.ResultThe study showed that N. sativa ethanol extract effectively inhibit histamine release from peritoneal Wistar rat mast cells proportionally to its concentration. N. sativa is effective as an anti-inflammation on mast cells by inhibition of histamine release and has no toxic effect on mast cell. N. sativa could be considered as a potential therapy for asthma therapy and prevention.

Background: Silica, asbestos and coal dust are associated with pneumoconiosis in mining workers. The International Labor Organization (ILO) reports that 30-50% of workers in developing countries are diagnosed with pneumoconiosis. This study aims to identify pneumoconiosis in limestone mining workers in Indonesia. Method: This cross-sectional study involved 73 subjects of limestone mining workers in Citatah Village, West Bandung Regency, Indonesia. Two conclusions were similar from three AIR-Pneumo certified photo readers by blind reading and using the ILO guidelines. Result: Pneumoconiosis was found in 11/73 (15.1%). The median age of the pneumoconiosis group was older than the non-pneumoconiosis group (51 [33-63] vs. 37.5 [18-85] age in years, p = 0.013). All subjects in the pneukoniosis group worked> 6 years (p = 0.001). The highest dust concentration was in the pneumoconiosis group compared to the non-pneumoconisosis group (61.41 ± 103.98 vs. 14.92 ± 55.17 mg / m3, p = 0.030). This study showed that the length of work and the level of dust in the mine were risk factors for pneumoconiosis, although not significant (OR = 14.6, p = 0.999 and OR = 7,171, p = 0.998). Conclusion: The proportion of pneumoconiosis in lime mining workers in this study was 15.1%. Length of work and dust levels in the mine are risk factors for pneumoconiosis; but not meaningful in this study.

Background: One of the most common occupational diseases found in workplace is pneumoconiosis. The most disease is silicosis, which is lung disease caused by inhalation of dust containing free crystalline silica which afflicts tens of millions of workers in hazardous work and kill thousands of people worldwide. This study aimed to determine proportion and radiologic appearance of pneumoconiosis in workers exposed to dust in various industrial and mining processes. Method: This research used cross-sectional desaign, was conducted 2017 until September 2019 for various industrial and mining workers exposed to dust. Chest X-ray with digital radiography was read in International Classification of Pneumoconiosis Radiography from ILO version 2011, by a lung specialist who certified by The International Labor Organization (ILO) and The Asian Intensive Reader of Pneumoconiosis Project (AIR Pneumo). Results: ILO chest X-ray readings were carried out on 810 chest photos. Various radiological features of pneumoconiosis were obtained in 132 chest X-rays (16.2%), mostly abnormalities in parenchyma 87.1%. Parenchymal abnormalities are mostly of small round (p/p) with a profusion of 0/1 (89.6%). The most zones were lower right (58.1%). Pleural disorders (2%) mostly of costophrenic sinus obliteration 64.8%. Other disorders were 61/810 (7.24%), mostly of diaphragm abnormalities 15/61 (27.9%). Relevant appearance with pulmonary tuberculosis (infiltrates) was 8/810 (0.9%). Conclusion: The proportion of pneumoconiosis was 16.2%, mostly of parenchymal abnormalities (87.1%). Parenchymal abnormalities that occured still in the early phase, most zones were lower right (58.1%), pleural disorders 2%, other abnormalities were 7.24% and those that relevant to pulmonary tuberculosis 0.9%. (J Respir Indo. 2019; 39(4): 266-71)

The holy city of Makkah is one of the big cities in Saudi Arabia that is densely populated, especially during the Hajj season. In recent years, air pollution in Makkah has been a growing problem due to construction activities, motor vehicle fumes, rising temperatures, rainfall and humidity. The higher the level of air pollution exposure, the more it has an impact on human health, especially the lungs and airways. The health impacts associated with air pollution include an increase in the incidence of respiratory infections, asthma, chronic obstructive pulmonary disease and other lung diseases. Better knowledge of the correlation between air pollution and lung and airway diseases will contribute to developing more strategies to reduce air pollution in the holy city of Makkah.