Objective: To investigate the difference in effectiveness of Eutectic Mixture of Local Anesthetics (EMLA) and Benzocaine as a topical anesthetic in palatal injection Methods: Forty volunteers from dental department at Prince Ali Bin Al Hussein Military Hospital participated in the study. 5% EMLA cream or 20% Benzocaine gel were applied to either side of the hard palate opposite the maxillary first premolars. A short needle was inserted at site of topical anesthetic application at 3, 6 and 9 minutes until it touches the bone and the volunteers assisted the pain on a visual analogue scale (VAS) where 0 indicated "no pain" and 10 indicated "unbearable pain" Results: EMLA found to be associated with less pain than Benzocaine at all applied times and the difference was statistically significant (p < 0.05). There was no significant difference between intergroups of EMLA or between those of Benzocaine. EMLA found to be associated with less VAS values than Benzocaine and the difference was statistically significant Conclusion: 5% EMLA was more effective than 20% Benzocaine gel as a topical anesthetic agent in palatal injection.