Ventral hernia, a commonly dealt surgical problem in clinical practice, is dened as an abnormal protrusion of a viscus or a part of the viscus through a defect or weakness in the anterior abdominal wall. Various risk factors such as old age, history of previous surgery, obesity, COPD, diabetes mellitus, smoking & alcoholism lead to the formation of ventral hernias. Mesh hernioplasty has become the gold standard in the management of ventral hernias. There are various procedures in the management of ventral hernias based on the placement of mesh. In this study, we compare the traditional onlay and retro-rectus mesh repair in ventral hernias in terms of postoperative complications, hospital stay & feasibility

The aim: to assess levels of circulating plasma ox-LDL in various subgroups with different CVD and their relationship with oxidative stress markers, MDA, catalase, and traditional coronary disease risk factors. Material and methods: a total of 215 subjects divided into four groups comprising 54 healthy controls, patients with the SAP were 52 persons, with the UAP 53 ones, and with the AMI there were 56 persons, respectively. Lipid profile parameters (TC, TG, HDL-C, LDL-C, and VLDL-C), plasma MDA, catalase were estimated by kit methods, TBARS method, and colorimetric assay respectively. Plasma Ox-LDL was estimation by competitive ELISA kit method (Mercodia) with the help of specific monoclonal antibody mAb4Eb. Results were present as mean ± SD, significance level at p-values<0.05 with Student’s unpaired t-test. Data analysis was performed by software package SPSS version 17.0. Results: it showed a highly significant (p<0.001) correlation in SAP, UAP, and AMI except for age in the SAP subgroup, moderately significant (p<0.01). Lipid profile except HDL-C was found highly elevated (p<0.001) in subgroups than in healthy controls. HDL-C was higher (p<0.001) in controls with respect to patient subgroups. Comparison of oxidative stress markers (MDA and catalase) and ox-LDH in control with patient’s subgroup indicates highly significant (p<0.001) correlation. The correlation between SAP & UAP was insignificant (p<0.05), SAP with AMI was significant (p<0.05), and UAP & AMI were highly significant (p<0.001). Large interquartile range in SAP subgroup suggesting scattered deviation in the mean value as compared to UAP and AMI showed in the box and whiskers plot and concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD. Conclusions: study concluded that significantly elevated level of ox-LDL in SAP, UAP, and AMI subgroups indicate its diagnostic importance of CVD.

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Background: Childhood tuberculosis is difficult in the identification of the organism due to impropersampling as well as low sensitivity of the smear. Newer diagnostic methods like Cartridge basednucleic acid amplification tests (CBNAAT) can rapidly identify Mycobacterium tuberculosis withimproved sensitivity over the smear testing. Material & Method:This observational record basedcross-sectional study was undertaken to identify the epidemiology of tubercular infection in childrendiagnosed with CBNAAT. The study was carried out by analyzing the data of children from six monthsto 18 years who were diagnosed with Tuberculosis and treated with anti-tuberculosis therapy (ATT)from April 2018 to March 2020. Results: Data of a total of 166 patients was analyzed. 42% ofoverall collected samples were reactive to CBNAAT testing for tuberculosis. 40 gastric aspiratesamples were collected and only four (10%) turned reactive for tuberculosis by CBNAAT. None of thepediatric samples was positive for MDR TB. 66% of children completed treatment and 33% weredeclared cured. Conclusion: 42% positivity after CBNAAT testing for tuberculosis infection incollected samples of sputum and gastric aspirate where only 10% yield in GA samples.