Background: Prediabetes is determined on the bases of glycemic parameters, which are above normal but below diabetic thresholds. Prediabetes is associated with the presence of insulin resistance and β-cells dysfunction. N-acetyl cysteine (NAC), as a safe and inexpensive medication, is commercially accessible since long-time ago. This drug is not found in natural sources, although cysteine is present in some meals like chicken and turkey meats, garlic, yogurt, and eggs. NAC prevents apoptosis and oxygen related genotoxicity in endothelial cells by increasing intracellular levels of glutathione and decreasing mitochondrial membrane depolarization reaction. Objective: To evaluate the effects of NAC administration on glucose homeostasis parameters in prediabetic patients. Methods: This study included, 25 patients treated with dietary control and life style modifications for 12 weeks, 25 patients treated with NAC (600 mg) oral tablets twice daily plus dietary control and life style modifications for 12 weeks. Other 20 in addition to 50 patients to have an idea about the normal values of study parameters and in order to assess how much the drug used in the study were able to normalize the abnormal parameters. Results: NAC demonstrated a significant decrease in the fasting blood sugar, HbA1c, fasting Insulin and insulin resistance at the end of 12 weeks (P<0.05) compared with baseline measurements. Conclusion: The results of the study showed that N-acetyl cysteine has an effective effect on glycemic control. Keywords: Prediabetes , N-acetyl cysteine , glycemic control Citation: Abu Raghif AR, Yaseen YA, Dawood MH. Effects of N-Acetyl-Cysteine (NAC) administration on glucose homeostasis parameters in prediabetic patients. Iraqi JMS. 2018; 16(4): 393-399. doi: 10.22578/IJMS.16.4.6

This study has assessed the effect of coenzyme Q10 among patients with systolic and diastolic blood pressure of prehypertensive of 50 participants including 30 males and 20 females were selected for this research according to their clinical diagnosis of prehypertensive symptoms, the study was placed in were seen in Al-Sader Teaching Hospital, in Misan hospital, IRAQ. The patients were divided by half into the control group and the other group which received the Q10 within their diet and lifestyle for 12 weeks. The results showed that the daily consumption of coenzyme q10 (200mg) with significant improvements in both systolic and diastolic blood pressure in prehypertensive patients.