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Background Using the extraoral indicators is a common method to determine the size and shape of the artificial teeth. Aim This study was conducted to assess the relationship between the mesiodistal width of maxillary central incisors and some facial anatomical landmarks (Bizygomatic and Inter-canthal distance). Materials and Methods A prospective cross-sectional study was conducted on 160 adult students, with the age range between 18-25. Mesiodistal widths of maxillary central incisors and two facial widths (bizygomatic and inter-canthal) were marked and measured by digital caliper to the nearest of 0.01mm. Data were analyzed statistically using SPSS (V-18) software. Results The statistical Analysis demonstrated the correlation of the mesiodistal width of a right central incisor with bizygomatic and inner-canthal widths was significant at P-Value of (P< 0.05), Spearman›s correlation of bizygomatic for male was 0.358 and female was 0.305, and the spearman›s correlation of intercanthal for male was 0.318 and female was 0.312. In the male, the correlation of the mesiodistal width of a left central incisor with bizygomatic and intercanthal widths was weak; Spearman›s correlation was 0.043 for bizygomatic and was 0.123 for intercanthal. While for female, it showed a strong correlation, spearman›s correlation was 0.349 for bizygomatic and was 0.298 for intercanthal. Conclusion The results proposed that the inter-canthal and bizygomatic widths are both good prognostic factor in determining the mesiodistal width of the maxillary right central incisor. Also concluded that the correlation between maxillary central incisor width and bizygomatic and inter-canthal widths could be differed by gender.