Introduction: Stroke is a devastating neurological condition. No recent studies conducted in the Western Region of Saudi Arabia regarding stroke. Therefore, our aim is to assess the awareness towards early manifestations of acute stroke among adults in the Western Region and to identify a relationship between the level of awareness and different sociodemographic data. Method: A cross-sectional study will be conducted by using validated questionnaire among general public from July 2022 to November 2022. The data will be collected through social media. Result: A total of 352 participants completed the questionnaire. Almost (67%) were female, majority from Medina Province (76.1%), about 92.0% have heard about the terminology Stroke. Good awareness was leaning towards younger age groups. Furthermore, educational level has a significant difference on the level of awareness on stroke symptoms manifestations at p-value = 0.001, others demographic factors are not correlate with the level of awareness regarding stroke. Conclusion:The percentage of participants with good awareness was almost the same as that of those with poor awareness, therefore, this knowledge gap must be fixed to improved prevention.