Sulfonylurea derivatives are zinc metalloenzyme modulators.

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Hybrid antimicrobials that combine the effect of two or more agents represent a promising antibacterial therapeutic strategy.

Synthetic methods providing access to sulfonylureas are immensely valuable considering the wide usage of sulfonylurea derivatives as hypoglycemic drugs and herbicides. In this work, the scope of a sodium cyanate mediated single-step synthesis of sulfonylureas from amines and sulfonyl chlorides as starting materials has been examined. Success of the single-step reaction in affording desired aliphatic and aromatic sulfonylurea products depends on the combination of suitable nucleophilicity of amines and reactivity of sulfonyl chlorides. In addition to providing access to sulfonylureas, the interplay of reactivities of the amine and sulfonyl chloride is found to result in emergence of specific oligomeric products that are characterized as novel sulfonyltriurets. In effect, the sodium cyanate mediated single-step reaction for synthesis of sulfonylureas also provides a method for synthesis of specific sulfonyltriurets. Electronic effects accompanying the amine and sulfonyl chloride modulate the nature of major product between sulfonylureas and sulfonyltriurets. The sodium cyanate mediated single-step reaction is thus sought to be considered as a method for synthesis of sulfonyltriurets in addition to sulfonylureas.