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Globally, motorcycle riders make up the biggest percentage of vulnerable road user fatalities. The percentages are higher in African cities where moto-taxi transport is not only the most readily available mode of transport but also a source of income for many especially the youth. Many African cities are re-strategizing on how to sustainably deal with problems like traffic congestion, unplanned development, flooding, air and noise pollution. The authors carried out a questionnaire survey targeting a variety of road safety stakeholders to identify road safety solutions that they think best fit the current situation. Another questionnaire survey targeting moto-taxi riders was carried out, and the data analyzed by SEM to identify how different solutions interact to affect the behavior of riders. Results show that education and training programs have the biggest effect on improving behavior of riders as they adapt to new city regulations such as zoning. Other aspects such as presence of customers, behavior of other road users, road environment were also explored. Currently, city authorities in some developing nations are looking to introduce spatial regulations such as zoning and traffic management strategies such as exclusive lanes. Therefore, the contribution of this study is a proposal of a combination of solutions that different road safety stakeholders in developing countries can contribute toward the sustainable improvement of the safety of riders.