Among several multipurpose tree species in the eastern parts of Ethiopia, Sesbania sesban, Moringa oliefera, Gravilea robusta, Cordia africna, Azadarichta indica and Leuceana leucocephala are common. However, their adaptability and growth performance of this tree species has not scientifically trailed in the study area. Therefore, the study was conducted to evaluate the adaptability of multipurpose tree species at Babille District, Oromia, Ethiopia, for three years (June 2016 - June 2019). The experiment was laid out in RCBD with three replications. Data on the growth parameters; diameter, plant height and survival rate were measured and recorded at interval of three months. Results revealed that there were highly significant (p <0.05) variations among tree species in height growth, RCD, DBH and survival rate at the study area. Among the species tasted, M. oliefera showed the highest performance followed by A. indica, S. sesban and L. leucocephala in terms of height growth, RCD and DBH at Babille condition. after three years of establishment, M. oliefera, A. indica, S. sesban and L. leucocephala showed the highest mean survival rate at the study area. Hence it can be inferred that the conditions of Babille district matched with the environmental requirement of those tree species. On the other hand, species of G. robusta showed lowest performance at the study area. Thus, the long dry season, which extended from eight to ten months in the study area, clearly explains the poor survival and growth response in some of the species. Generally, the study under Babille condition and related agro-ecology, we advocate these adapted species and properly allocate species into the site that grow and adapt well for further agroforestry practices at wider scale on which success of agroforestry practices and forest plantations depend.