This study attempts to determine whether the prolonged stay of people in an unfavorable environment, in our case the oil and gas (OG) region, affects their psychophysical health, makes them vulnerable, prone to psychosomatic diseases, creates psychological problems, or leads to internal conflicts. Participants (typically healthy people) were asked to answer questions based on the multidimensional fatigue inventory (MFI-20). The scale reflects the following five main dimensions of fatigue: General fatigue, physical fatigue, reduced activity, mental fatigue, and reduced motivation. Three of them, namely general fatigue, physical fatigue, and mental fatigue, are of particular importance for this work. The study revealed the psychological profiles of the population of the study region and concluded that the OG region poses a significant risk to public health with all the ensuing consequences.