This study assessed the nature, prevalence, and risk factors of musculoskeletal symptoms (MS) in dental clinics. A self-administered questionnaire was completed by 515 dental students and dentists about nature of work and prevalence and frequency of MS symptoms. Chi-square and logistic regression were used to determine the association of MS with a number of important variables. Pain in the lower back (64%) and neck (60%) were the most prevalent MS. Working in the dental colleges' clinics was associated with increased risk of MS (adjusted OR 2.30, 95% CI [1.27, 4.18]). A stronger association was observed for dentists working in the private clinics (adjusted OR 2.58, 95% CI [1.28, 5.17]). Female dentists were at more risk of MS than male participants (OR 1.63, 95% CI [1.02, 2.59]). The higher risk of reported MS symptoms in women and for those working in the dental colleges and private clinics underscores the importance of recognition and prevention of MS symptoms even early in the dental profession.