Given the clinical, endoscopic, and bacteriological examination results, it is believed that Campylobacter spp. are agents that cause flare-up clinically by being superimposed on the primary disease, rather than agents that initiate the disease in patients with UC. Arcobacter spp., which are known to cause acute gastroenteritis, were not found to be associated with UC.

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Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), and the overall burden is increasing at the global level. Differences in perceptions of UC-related burden may highlight dramatic degree insufficient patient-physician communication. ICONIC is a prospective, non-interventional, observational study assessing disease burden in adults with UC using Pictorial Representation of Illness and Self Measure (PRISM). The local results of ICONIC study for Turkey are presented. Methods Patients aged ≥18 years with early UC (diagnosed ≤36 months) were enrolled. At baseline and every 6 months, patient and physician reported outcomes were collected using PRISM, the Simple Clinical Colitis Activity Index (SCCAI and P-SCCAI), The Rating Form of IBD Patients’ Concerns (RFIPC), the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and the Patient Health Questionnaire-9 (PHQ-9). Correlations between the patient assessed PRISM and other measurement tools were evaluated with Pearson correlation coefficient. Results One hundred and twenty patients were included (77 [64.2%] female; mean age 35.2 years). Physician-assessed disease severity was: severe 23 [19.2%], moderate 42 [35.0%], mild 40 [33.3%], in remission 15 [12.5%]. The mean ± SD physician- and patient-assessed PRISM scores were 4.8 ± 2.3 cm (range: 0.0–9.0) and 4.1 ± 2.6 cm (range: 0.0–8.5) at baseline and increased to 6.1 ± 2.3 cm (range: 0.1–8.5) and 5.5 ± 2.7 cm (range: 0.0–9.3) at the final visit, respectively, indicating an improvement in the perceived disease burden. The mean values of physician-SCCAI and P-SCCAI were 3.8 ± 3.5 and 5.5 ± 4.3 at baseline and decreased to 1.4 ± 2.5 and 2.7 ± 3.2 at the final visit, respectively, showing a decrease in disease activity. At baseline, the RFIPC and PHQ-9 values were 2.7 ± 1.7 and 8.0 ± 5.5 and decreased to 2.2 ± 2.0 and 5.2 ± 4.5 at the final visit, respectively. Patient-assessed SIBDQ was 43.8 ± 14.5 at baseline and increased to 54.0 ± 13.0 at the final visit. The strongest correlation of patient-assessed PRISM was with the physician-assessed PRISM (Spearman rho = 0.69, p<0.0001), followed by SCCAI (rho = -0.56, p<0.0001). Differences between physician- and patient-assessed PRISM scores were statistically significant (baseline: p=0.0010 vs. final visit: p=0.0206), highlighting an underestimation of patient’s suffering by physicians. Conclusion In the Turkish ICONIC sub-study, majority of patients on treatment showed improved outcomes during the follow-up period. A moderate correlation between patient-assessed PRISM and other measurement instruments represents that PRISM may be used as surrogate marker for patient suffering.

Short bowel syndrome occurs as a result of insufficiency in the total length of the small intestine to provide adequate supply of nutrients. Seventy-five percent of cases are due to massive intestinal resection. A 35-year-old male complaining of abdominal pain was admitted to the gastroenterology department. A CT scan was performed, showing total occlusion of the portal vein and superior mesenteric vein. During the operation, widespread edema and necrosis of the small intestine were found. The necrotic segments of the small intestine were resected. The spleen was larger than normal and, in some parts, infarcts were evident, thus asplenectomy was also performed during surgery. A second-look procedure was performed 24 hours later, and an additional 10 cm jejunal resection and anastomosis was performed. His further evaluations revealed myeloproliferative disease and chronic active hepatitis B leading to thrombosis. Essential thrombocytosis and portal vein thrombosis are common in hepatitis B infection. Patients with complaints of abdominal pain in the context of essential thrombocytosis and hepatitis B should be handled with caution as they are at risk of developing portal vein thrombosis.Key Words: Portal vein thrombosis, myeloproliferative disease, hepatitis B INTRODUCTIONShort bowel syndrome results from the inability of the total length of the small intestine to provide adequate nutritional support. Seventy-five percent of cases are caused by massive intestinal resection (1). In adults, mesenteric occlusion, midgut volvulus and traumatic avulsion of superior mesenteric veins are the most common causes (1). In this article, an atypical short bowel syndrome resulting from portal vein thrombosis that occurred in a patient with JAK 2 positivity and chronic active hepatitis B, will be presented. CASE PRESENTATIONA 35-year old male patient complaining of abdominal pain was admitted to the gastroenterology clinic. After obtaining informed consent from the patient examinations were started. The WBC: 8.87x10 3 / μL, hemoglobin 14 g/dL, and platelet were 626x10 3 /μL. The abdominal ultrasonography revealed splenomegaly and portal vein thrombosis, and the upper gastrointestinal endoscopy identified prominent esophageal submucosal veins. The abdominal computed tomography showed complete occlusion of the portal and superior mesenteric veins and splenomegaly ( Figure 1). Due to aggravation of the patient's abdominal pain and increasing white blood cell count (22x10 3 /μL) an emergency operation was decided. During the operation, generalized edema and necrosis in the small bowel loops, from 55 cm. distal to the ligament of Treitz up to 35 cm proximal to the ileocecal valve was identified ( Figure 1). The necrotic bowel segment was resected. The spleen was larger than normal and contained areas of infarction, thus splenectomy was performed. Since there were concerns regarding the viability of the remaining small intestine, a second-look operation was planned and the patient was transferred to the General Surgery Intensive Care...

Gastroözefageal reflü hastalığı; alt özofagus kapağının işlevini yitirmesi üzerine midedeki besinlerin yemek borusuna geri kaçışı olarak tanımlanmaktadır. Teşhisi invaziv tekniklerle yapılmaktadır. Teşhiste altın standart olarak ph-metre tekniği kabul edilmektedir ve bu yöntem bazı dezavantajlara sahiptir. Elektrogastrogram (EGG) mide elektriksel aktivitesinin deri yüzeyinden elektrotlar ile non-invaziv ölçümüdür. Bu çalışmada, Gastroözefageal reflü hastaları ve sağlıklı bireylerden kaydedilen EGG sinyalleri Ayrık Dalgacık Dönüşümü (ADD) ve Güç Spektral Yoğunluğu (GSY) grafikleri kullanılarak analiz edilmiştir. Bu çalışmadaki temel amaç, reflü hastalığının teşhisini EGG sinyalleri ile sağlayabilecek özellikler elde etmektir. Gerçekleştirilen çalışma sonucunda kullanılan tekniklerle, reflü hastalarına ve sağlıklı bireylere ait EGG sinyallerini ayırt edebilecek öznitelikler elde edilmiştir. Ayrıca Reflü hastalığının teşhisi için elektrotların yerleşiminde kullanılacak en uygun noktaların seçimi sağlanmıştır.