Aim: In this study, we aimed to compare the two-dimensional predictions made by two computer software packages with the postoperative values, and thus to evaluate the clinical reliability of digital orthognathic surgery planning. Methodology: Orthodontic treatment was performed before orthognathic surgery, and the same surgical team performed double-jaw orthognathic surgeries. We included 20 individuals (10 females, 10 males) with skeletal Class III malocclusion. The average age of the individuals was 21.5 years. In our study, the amount of movement was determined using reference lines on lateral cephalometric radiographs obtained from the preoperative and postoperative Cone-Beam Computed Tomography (CBCT) records of 20 individuals. Prediction profiles were formed using Dolphin Imaging (Dolphin Imaging & Management Solutions, Chatsworth, CA, USA) and NemoFAB 2D (Software Nemotec, S.L, Spain) computer softwares. In this way, the reliability and consistency of two-dimensional prediction software were examined. Results: The prediction profiles obtained from the computer software were compared with lateral cephalometric radiographs of the postoperative surgery results for 37 cephalometric parameters. There were no significant differences between software predictions and postoperative results in any cephalometric parameters. Conclusion: The plans and predictions made with the two computer software packages were reliable and can be used clinically.   How to cite this article: Balkı M, Doğru M. Evaluation of two different imaging software programs in planning orthognathic surgery cases. Int Dent Res 2022;12(2):70-81. https://doi.org/10.5577/intdentres.2022.vol12.no2.5   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.