In this study, we revealed that palonosetron did not cause any severe rhythmic disorders or symptomatic ECG changes. We concluded that it could be safe to administer palonosetron antiemetically.

Objectives Platelet/lymphocyte ratio is considered to be a recent biomarker which is not only related with inflammation but also associated with the atherosclerotic process. In this study, we aimed to investigate the relationship between carotid artery stenosis, platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, and mean platelet volume in patients undergoing carotid endarterectomy. Methods A total of 160 patients (127 males, 33 females; mean age 69.98 ± 9.76 years; range 48–92 years), who were undergoing carotid endarterectomy due to severe carotid artery stenosis, were evaluated and compared with 201 patients (140 males, 61 females, mean age 66.30 ± 9.24 years, range 41–90 years) without severe carotid artery stenosis. The patients were divided into four groups with respect to the carotid artery stenosis as: Group I (<50% stenosis), Group II (50–70% stenosis), Group III (70–90% stenosis), and Group IV (90–99% stenosis). Results Platelet/lymphocyte ratio, neutrophil/lymphocyte ratio and mean platelet volume were found higher in Group IV (patients with severe carotid artery stenosis) (p < 0.01) and were positively correlated with the degree of stenosis (p < 0.01). Platelet/lymphocyte ratio is an independent predictor for post operative stroke (p = 0.047) at multivariate analysis. A threshold level of 145.304 of platelet/lymphocyte ratio combined with a sensitivity 83.3% and specificity 73.8% (95% CI, 0.802–0.921, area under the curve = 0.862 ± 0.03; p = 0.002) for the identification of post operative stroke. Conclusions This retrospective study suggests that platelet/lymphocyte ratio in the blood which was taken preoperatively could be considered as an additional, easy, and inexpensive method to predict a possible higher incidence of postoperative stroke after carotid endarterectomy.

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Bu çalışmada majör vasküler cerrahi yapılan hastalarda ameliyat öncesi nötrofil-lenfosit oranının (NLR) ve trombosit-lenfosit oranının (PLR) prognostik bir rolü olup olmadığı ve sağkalım ile olan ilişkisi araştırıldı. Ça lış ma pla nı: Haziran 2005 ve Aralık 2012 tarihleri arasında majör vasküler cerrahi yapılan 838 ardışık hasta (593 erkek, 245 kadın; ort. yaş 63 yıl; dağılım 10-99 yıl) çalışmaya alındı. Mutlak nötrofil ve trombosit sayısının mutlak lenfosit sayısına bölünmesi ile NLR ve PLR hesaplandı. Bul gu lar: Ortalama mortalite riski NLR ≥5 olan hastalarda 2.85 (dağılım 1.67-4.87), PLR ≥200 olan hastalarda 3.76 (dağılım 2.31-6.12) idi. Diyabet hastalarının oranı, NLR ≥5 (%63.7; p= 0.000) ve PLR ≥200 olan hastalarda (%53.8; p= 0.003) anlamlı düzeyde daha yüksekti. So nuç: Çalışma bulgularımız artmış NLR ve PLR'nin ameliyat sonrası mortalite ile doğrudan, sağkalım ile ters ilişkili olduğunu ve diyabetli hastaların daha yüksek risk altında olduğunu gösterdi. Anah tar söz cük ler: Nötrofil-lenfosit oranı; trombosit-lenfosit oranı; vasküler cerrahi. Background: This study aims to examine whether preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) had a preoperative prognostic role and its association with survival in patients undergoing major vascular surgery. Methods: Between June 2005 and December 2012, 838 consecutive patients (593 males, 245 females; mean age 63 years; range, 10 to 99 years) who underwent major vascular surgery in our clinic were included. The NLR and PLR were determined by dividing the absolute neutrophil and platelet count by the absolute lymphocyte count. Results: The mean mortality risk was 2.85 (range 1.67-4.87) in patients with a NLR of ≥5 and 3.76 (range 2.31-6.12) in patients with a PLR of ≥200. The proportion of diabetic patients was significantly higher for patients with NLR ≥5 (63.7%; p= 0.000) and PLR ≥200 (%53.8; p= 0.003). Conclusion:Our study results showed that increased levels of NLR and PLR were directly correlated with mortality and inversely correlated with survival in the postoperative period and that diabetic patients were under a higher risk.

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