Oxidative stress is believed to contribute to neurodegeneration following ischemic injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of curcumin (Cur) on neuronal death of hippocampal CA1 neurons following transient forebrain ischemia in rat. Treatment of Cur (200 mg/kg/day, i.p.) at three different times (immediately, 3 h and 24 h after ischemia) significantly (P<0.01) reduced neuronal damage 7 days after ischemia. Also, treatment of ischemic rats with Cur decreased the elevated levels of MDA and increased GSH contents, catalase and SOD activities to normal levels. In the in vitro, Cur was as potent as antioxidant (IC(50) = 1 microM) as butylated hydroxytoluene. The present study demonstrates that curcumin treatment attenuates forebrain ischemia-induced neuronal injury and oxidative stress in hippocampal tissue. Thus treatment with curcumin immediately or even delayed until 24 h may have the potential to be used as a protective agent in forebrain ischemic insult in human.

Abstract:The machinability of graphene-reinforced magnesium-based hybrid nanocomposites produced through the application of powder metallurgy method has not been completely reported. This article presents an experimental investigation on the thrust force, the surface roughness (R a ), and drilled surfaces characteristics in the drilling process of a Mg/SiC/GNPs (magnesium matrix based silicon carbide and graphene nanoplatelets) hybrid magnesium matrix composite. The hybrid composite material was produced through the application of a powder metallurgy method. The experiments were carried out with uncoated, PVD (Physical Vapor Deposition), and CVD (Chemical Vapor Deposition) coated tungsten carbide drill bits at three levels of cutting speeds (30, 40, and 50 m/min), and three different levels of feed rate (0.10, 0.15, and 0.20 mm/rev) under dry machining conditions. Taguchi's L 27 (3 3 ) orthogonal array and S/N ratio were used to optimize the optimal parameters for thrust force and surface roughness. The experimental results indicated that the thrust force and the surface roughness were extremely dependent on a particular type of drill bits, feed rate, and cutting speed. The feed rate parameter is known to have a significant influence on the surface finish.

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