The extracellular matrix (ECM) is an environment that has various enzymes attended in regeneration and restoration processes which is very important to sustain physiological and biological functions of central nervous system (CNS). One of the participating enzyme systems in ECM turnover is matrix metalloproteinases. A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS) is a unique family of ECM proteases found in mammals.Components of this family may be distinguished from the ADAM (A Disintegrin and Metalloproteinase) family based on the multiple copies of thrombospondin 1-like repeats. The considerable role of the ADAMTS in the CNS continues to develop. Evidences indicate that ADAMTS play an important role in neuroplasticity as well as nervous system pathologies such as Alzheimer's disease (AD). It is hopeful and possible that ADAMTS family members may be utilized to develop therapies for CNS pathologies, ischemic injuries, neurodegenerative and neurological diseases. To understand and provide definitive data on ADAMTS to improve structural and functional recovery in CNS injury and diseases, this review aimed to enlighten the subject extensively to reach certain information on metalloproteinases and related molecules/enzymes. It will be interesting to examine how ADAMTS expression and action would affect the initiation/progression of above-mentioned clinical situations, especially AD.

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Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.

Seramik sağlık gereçleri üretim sürecinde, ürünler birçok faktöre bağlı olarak deformasyonlara maruz kalırlar. Bunun temel sebebi, seramiğin fiziksel ve kimyasal değişime uğramasıdır. Deformasyon oluşumunu önlemek için, tasarım aşamasından, fırın çıkışına kadar geçen süreçte çeşitli çalışmalar yapılmaktadır. Bunun yanında, deformasyon oluşumunu önlemek veya oluşan deformasyonu gidermek için bazı aparatlar geliştirilmiştir. Bu aparatlar genellikle işletme şartlarına bağlı olarak, belirli bir üretim tecrübesi sonucunda tasarlanırlar. Her ürün için karşılaşılan sorunlara farklı çözüm yöntemleri geliştirmek mümkündür. Bu çalışma kapsamında, sağlık gereçleri üretimi yapan iki farklı seramik fabrikasında, deformasyonu önlemek için geliştirilen aparatlar incelenmiş, deneme ürünler üzerinde uygulamalar yapılarak fırın çıkışı olumlu sonuç alındığı gözlenmiştir. Geliştirilen bu aparatlar aracılığıyla, seramik sağlık gereçleri üretiminde karşılaşılan, ürün çökmeleri, ürün eğilmeleri ve eğrilik/ peçlik oluşumu gibi deformasyon sorunlarının, seri üretimde de giderildiği kayda alınmıştır.

Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disease that mostly affects the elderly population. Recent studies performed in AD highlight the pathophysiological relevance of disintegrin and metalloproteinase with thrombospondin type 1-like motifs (ADAMTS) genes and their products, namely hypoxia inducible factor-1 (HIF-1) and thrombospondin-1 (TSP-1). Thus, the aim of this study was to describe and identify the distribution, characteristics, and any changes in the expression and immunoreactivity for HIF-1, TSP-1, and ADAMTS1 and 8 in AD brains. Materials and Methods:Nine patients who were autopsied in the Council of Forensic Medicine, Bursa Morgue Department in 2013, were selected. All patients were sent for autopsy to the Morgue Department within 8 h after death. At the autopsy, tissue samples of the organs were obtained for histopathological examination for determining the cause of death. Among these, two patients were clinically diagnosed with AD.Results: Immunohistochemical staining was performed, and the staining intensity/extensity was evaluated using a semiquantitative scoring system. Median distribution (extensity) scores of the immunohistochemical staining were estimated as 2 for HIF-1, 0.67 for TSP-1, 3.11 for ADAMTS1, and 2.78 for ADAMTS8. Intensity scores were estimated as 1.22 for HIF-1, 0.56 for TSP-1, 3 for ADAMTS1, and 2.11 for ADAMTS8. Conclusion:Our study suggests that ADAMTS1 and ADAMTS8 expressions are not specific for AD. To understand and provide definitive data on all aspects of metalloproteinases, extracellular matrix proteins, and transcriptional factor effects to AD, further studies are needed, where other metalloproteinases and related molecules/enzymes should be studied.