An experimental study was done to examine a potential role of phosphodiesterase (PDE) inhibitors in the treatment of diabetic erectile dysfunction. Relaxant effect of speci®c PDE inhibitors were measured in strips of corpus cavernosum smooth muscle taken from control and diabetic groups. Diabetes mellitus was induced in New Zealand white rabbits using alloxan. Penises excised from diabetic rabbits 8 weeks after the induction of diabetes mellitus. In the organ bath strips from control and diabetic rabbit corpus cavernosum were precontracted and increasing doses of several PDE inhibitors were added. In the precontracted rabbit cavernous tissue, sulmazole and zaprinast speci®c PDE V inhibitors were equally potent and ef®cacious in vitro but amrinone, a speci®c PDE III inhibitor, exhibits low relaxant effects. All PDE inhibitors tested showed a similar relaxation effect on corpus cavernosum smooth muscle from control and 8-week diabetic rabbits. The present study provides the possibility of using selective PDE III and V inhibitors in the treatment of diabetic impotence.

In this study, we define a new type of statistical limit point using the notions of statistical convergence with respect to the $J_p$ power series method and then we present some examples to show the relations between these points and ordinary limit points. After that we also study statistical limit points of a sequence with the help of a modulus function in the sense of the $J_p$ power series method. Namely, we define $f-J_p$-statistical limit and cluster points of the real sequences and compare the set of these limit points with the set of ordinary points.