Coronaviruses are a family of related viruses that cause diseases in mammals and avians. Guillain-Barre syndrome is a rare disorder in which the body's immune system attacks peripheral nerves.The case:A 65 years old Sudanese male with no diabetes mellitus or hypertension present to the clinic; On examination, he has upper and lower limb weakness (quadriplegia). The condition was preceded by upper respiratory tract infection. Chest X-ray showed features of pneumonia Chest CT scan showed multiple bilateral ground-glass opacities and consolidation typical of COVID-19 pneumonia. Brain MRI was normal. The COVID-19 nasal swab test was positive. Nerve conduction study showed evidence of polyradiculopathies with dominant demyelination supporting the diagnosis of Guillain-Barre syndrome. The patients died after seven days; because of progressive respiratory failure.

Introduction: Epilepsy is either; idiopathic when there is no underlying cause or secondary if there is an underlying cause of egg brain tumors, stroke. There is a strong in conjunction between epilepsy and valvular lesions. Objective: To study the relationship between valvular lesions and Epilepsy among Sudanese epileptic patients. Methodology: Almost 50 Sudanese patients with valvular lesions were included in the study during Jane 2018 to Jane 2019. Result: Out of 50 patients (48%) males while females (52%). Almost 40% of the patients were found to have generalized tonic colonic epilepsy, while 60% have focal epilepsy. Pure MS was the common valvular lesion observed. 14% of the patients had atrial fibrillation, especially with mitral stenosis .4% of the patients underwent valvotomy. Abnormal EEG was observed in 64% of the patients. Abnormal brain MRI was detected in 50% of the patients. Almost all the patients 100% diagnosed as having valvular lesions before being diagnosed with epilepsy. Conclusion: There is a strong relationship between valvular lesions and epilepsy, most probably due to association with coexist arrhythmias resulting in cerebral infarction, tight valvular lesions, and rarely follow valvotomy valvular replacement.

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