Chicken pox (Varicella) infection is generally present in children and caused by Varicella Zoster Virus (VZV). There are quite a number of case reports of hypercoagulable state leading to deep venous thrombosis (DVT) and other thromboembolic sequelae following varicella induced auto antibodies to natural anticoagulants in children. But such a clinical entity is rarely seen in adults. Here we report a rare case of CVST in an adult due to low protein S levels following varicella zoster infection.