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Traditional thermal stabilizers containing lead, cadmium, and barium are gradually being replaced by nontoxic, environment‐friendly thermal stabilizers. Zinc‐based and organic‐based thermal stabilizers gain momentum in the market space. Organic thermal stabilizers that are completely free of metals, represent the current trend in the development of PVC thermal stabilizers for industrial applications. These trends in the development of thermal stabilizers for PVC, as well as novel uracil derivative‐based thermal stabilizers for PVC, are discussed in this article.