The outbreak of Covid-19 presents an unprecedented threat to public health with a devastating effect on the world economy and health system. In March 2020, the government of the United States responded by adopting the use of face masks as one of the measures to prevent the spread of coronavirus in public places. The increase in the spread of coronavirus necessitated the need for researchers to evaluate the effectiveness of face masks as a measure to control the spread of coronavirus. It became of more concern when alternatives to face masks were observed in public places. This article reviewed factors that affect the effectiveness of face masks and the choice of an effective face mask as reported by several studies. The use of appropriate face masks and other measures to prevent the spread of coronavirus should be encouraged at all levels. Keywords: COVID-19, SARS-CoV-2, FACE-MASKS.