Background: The present study was undertaken to evaluate the comparative results of “Modified Closed Lateral Internal Sphincterotomy (LIS), Closed LIS, and Fissurectomy” technique in treating fissure-in-ano in terms of relief of symptoms, healing of wound, postoperative hospital stay, recurrence rate, and postoperative complications. Materials and Methods: A total of 120 cases with definite history of fissure and clinically diagnosed cases of fissure-in-ano were selected for the study. A final diagnosis was made after proctoscopic examination under anesthesia during operation. The type of procedure which was to be undertaken was done by letting patient pick up slips randomly where the name of the procedure was written. Total 120 slips were made with 40 slips of each procedure written in them. Postoperative period was closely monitored, and all the cases were meticulously followed for a variable period of time. Results: In the present study, 68% of the patients were male and 32% were female. It was more prevalent in the age group of 18–40 years. Forty patients underwent modified closed LIS, 40 underwent closed LIS, and remaining 40 patients underwent fissurectomy. Postoperative pain, operative time, duration of hospital stay, and recurrence rate were compared. Conclusion: Fissure-in-ano is a very painful condition and may cripple the daily activity of the patient. Encouragingly, high success rates were achieved in our patients with the modified closed LIS technique.